Molecular structure of Diphenyleneiodonium chloride, CAS Number: 4673-26-1
Diphenyleneiodonium chloride (CAS 4673-26-1)
See product citations (24)
Alternate Names:
Diphenyleneiodonium chloride is also known as DPI chloride.
Application:
Diphenyleneiodonium chloride is an inhibitor of NOS2 (iNOS), NOS3 (eNOS), and neutrophil NADPH oxidase.
CAS Number:
4673-26-1
Purity:
≥97%
Molecular Weight:
314.55
Molecular Formula:
C12H8ICl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Diphenyleneiodonium chloride is a compound extensively used in biochemical research due to its role as an inhibitor of flavoenzymes, particularly NADPH oxidase. It is employed in studies investigating the generation of reactive oxygen species (ROS) and their impact on cellular processes. By inhibiting NADPH oxidase activity, diphenyleneiodonium chloride helps researchers to elucidate the mechanisms through which ROS contribute to signaling pathways, oxidative stress, and cellular damage. Additionally, this compound is used to explore the physiological functions of flavoenzymes in various organisms. In the context of environmental research, diphenyleneiodonium chloride is also applied to study the detoxification processes and response to oxidative stress in plants and microorganisms. Its effectiveness in inhibiting electron transport makes it useful for dissecting complex redox processes within cells and tissues.
Diphenyleneiodonium chloride (CAS 4673-26-1) References
- Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. | Kono, H., et al. 2001. Am J Physiol Gastrointest Liver Physiol. 280: G1005-12. PMID: 11292610
- Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species. | Mendes, AF., et al. 2001. Mediators Inflamm. 10: 209-15. PMID: 11577997
- Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor. | Morré, DJ. 2002. Antioxid Redox Signal. 4: 207-12. PMID: 11970854
- G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium. | Scaife, RM. 2004. Mol Cancer Ther. 3: 1229-37. PMID: 15486190
- Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium. | Balcerczyk, A., et al. 2005. Biochem Pharmacol. 69: 1263-73. PMID: 15794948
- Selective and irreversible cell cycle inhibition by diphenyleneiodonium. | Scaife, RM. 2005. Mol Cancer Ther. 4: 876-84. PMID: 15956245
- Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. | Stuehr, DJ., et al. 1991. FASEB J. 5: 98-103. PMID: 1703974
- Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium. | Ragan, CI. and Bloxham, DP. 1977. Biochem J. 163: 605-15. PMID: 18140
- Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase. | Yea, CM., et al. 1990. Biochem J. 265: 95-100. PMID: 2154184
- Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body. | Acker, H., et al. 1989. FEBS Lett. 256: 75-8. PMID: 2806553
- The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages. | Hancock, JT. and Jones, OT. 1987. Biochem J. 242: 103-7. PMID: 3036079
- Involvement of Reactive Oxygen Species in ABA-Induced Increase in Hydraulic Conductivity and Aquaporin Abundance. | Sharipova, G., et al. 2021. Int J Mol Sci. 22: PMID: 34502052
- Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications. | Tew, DG. 1993. Biochemistry. 32: 10209-15. PMID: 8399148
Inhibitor of:
4933437F05Rik, ACAD-9, ACRC, AK2, CNOX, COQ5, COX6a2, CYB5D1, CYB5R2, DAAO, DHRS11, eosinophil peroxidase, ETR1, GCS-α-1, gp91-phox, gp91phox, Grx2, HADHSC, LRRC33, Luciferase, MsrA, NCB5OR, ND1, NDUFA (NADH:ubiquinone oxidoreductase subunit), NDUFB (NADH:ubiquinone oxidoreductase subunit), NDUFB10, NIBP, Nkx-6, NNT, NOS, NOS2, NOS3, NOXA1, NOXO1, NOXRED1, OTTMUSG00000021223, OTTMUSG00000022205, Oxr1, p22-phox, p47-phox, p67-phox, Prdx6-rs2, Prdx6b, PRX2, pyridoxal kinase, PYROXD2, RFESD, and Sptrx-2.Activator of:
gp91phox, T Neutrophil, and ZMAT2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diphenyleneiodonium chloride, 10 mg | sc-202584E | 10 mg | $148.00 | |||
Diphenyleneiodonium chloride, 25 mg | sc-202584 | 25 mg | $133.00 | |||
Diphenyleneiodonium chloride, 50 mg | sc-202584D | 50 mg | $311.00 | |||
Diphenyleneiodonium chloride, 100 mg | sc-202584A | 100 mg | $397.00 | |||
Diphenyleneiodonium chloride, 250 mg | sc-202584B | 250 mg | $925.00 | |||
Diphenyleneiodonium chloride, 500 mg | sc-202584C | 500 mg | $1801.00 |