Molecular structure of Trolox, CAS Number: 53188-07-1
Trolox (CAS 53188-07-1)
See product citations (39)
Alternate Names:
Trolox is also know as 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid.
Application:
Trolox is an antioxidant derived from water-soluble vitamin E
CAS Number:
53188-07-1
Purity:
≥97%
Molecular Weight:
250.29
Molecular Formula:
C14H18O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Trolox is an antioxidant derived from water-soluble vitamin E, with oxygen quenching activity. The activity of Trolox ranges between ferulic acid (sc-204753) and p-coumaric acid (sc-215648). Studies show that lipid peroxidation, cytotoxicity, and apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. It can quench free radicals and inhibit methylmercury (MeHg)-induced reactive oxygen species (ROS) generation in C6 glial cells. In addition, Trolox has demonstrated the ability to reduce cytotoxicity of Microcystis aeruginosa and microcystin-LR in Artemia franciscana nauplii.
Trolox (CAS 53188-07-1) References
- NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells. | Bian, X., et al. 2001. J Biol Chem. 276: 48921-9. PMID: 11679590
- Pleiotropic effects of fenretinide in neuroblastoma cell lines and multicellular tumor spheroids. | Cuperus, R., et al. 2008. Int J Oncol. 32: 1011-9. PMID: 18425327
- On the mechanism of Trolox as antiblinking and antibleaching reagent. | Cordes, T., et al. 2009. J Am Chem Soc. 131: 5018-9. PMID: 19301868
- HFE polymorphisms affect cellular glutamate regulation. | Mitchell, RM., et al. 2011. Neurobiol Aging. 32: 1114-23. PMID: 19560233
- ESR study of the singlet oxygen quenching and protective activity of Trolox on the photodecomposition of riboflavin and lumiflavin in aqueous buffer solutions. | Jung, MY. and Min, DB. 2009. J Food Sci. 74: C449-55. PMID: 19723181
- Protective efficacy of the antioxidants vitamin E and Trolox against Microcystis aeruginosa and microcystin-LR in Artemia franciscana nauplii. | Ruebhart, DR., et al. 2009. J Toxicol Environ Health A. 72: 1567-75. PMID: 20077231
- The in vitro effects of Trolox on methylmercury-induced neurotoxicity. | Kaur, P., et al. 2010. Toxicology. 276: 73-8. PMID: 20637824
- Trolox enhances curcumin's cytotoxicity through induction of oxidative stress. | Zheng, J., et al. 2012. Cell Physiol Biochem. 29: 353-60. PMID: 22508043
- Trolox inhibits osteolytic bone metastasis of breast cancer through both PGE2-dependent and independent mechanisms. | Lee, JH., et al. 2014. Biochem Pharmacol. 91: 51-60. PMID: 24929117
- The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells. | Okamoto, A., et al. 2016. BMC Anesthesiol. 16: 104. PMID: 27776485
- Nitrone-Trolox conjugate as an inhibitor of lipid oxidation: Towards synergistic antioxidant effects. | Socrier, L., et al. 2019. Biochim Biophys Acta Biomembr. 1861: 1489-1501. PMID: 31247162
- Trolox is more successful than allopurinol to reduce degenerative effects of testicular ischemia/reperfusion injury in rats. | Seker, U., et al. 2020. J Pediatr Urol. 16: 465.e1-465.e8. PMID: 32595071
- Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells. | Chen, Q. and Cederbaum, AI. 1998. Mol Pharmacol. 53: 638-48. PMID: 9547353
- Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation? | Pannala, AS., et al. 1998. Free Radic Biol Med. 24: 594-606. PMID: 9559872
- Peroxynitrite and brain mitochondria: evidence for increased proton leak. | Brookes, PS., et al. 1998. J Neurochem. 70: 2195-202. PMID: 9572308
Inhibitor of:
5730403M16Rik, Apoptosis, BLVRA, DEPP, FAM213A, Fullerene, gp91-phox, LOXL2, LRRC33, MPV17L, MsrA, NGAL, Nitrotyrosine, Ox-LDL R-1, Oxr1, PCB, Sptrx-2, ZCSL3, ZNF688, and ZnT-7.Activator of:
α2-Macroglobulin, catalase, DnaJC5γ, DNAS1L3, DNASE1L2, EG546335, ELAC2, FNDC8, GPx-7, GRXCR2, Hint2, Keap1, Ly-55B, Mel13, Myf-5, netrin-1, NXNL2, OKL38, PA26, PDGF-C, PHF21A, pHyde, R-PE, Ros, SSSCA1, TMUB2, TRFP, TRITC, Trx-2, UQCRHL, VSTM1, WDR75, and ZIP14.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trolox, 500 mg | sc-200810 | 500 mg | $38.00 | |||
Trolox, 1 g | sc-200810A | 1 g | $67.00 | |||
Trolox, 5 g | sc-200810B | 5 g | $235.00 | |||
Trolox, 25 g | sc-200810C | 25 g | $678.00 | |||
Trolox, 100 g | sc-200810D | 100 g | $1712.00 |