Lin-7Bb Inhibitors
Lin-7Bb inhibitors are chemical compounds that specifically target and modulate the activity of the Lin-7b protein, a member of the Lin-7 family. Lin-7b, also known as Veli-2, is involved in the assembly of protein complexes at cell junctions, especially at synapses in neurons and in epithelial cells. The inhibitors act by binding to key functional domains of Lin-7b, thereby disrupting its interactions with other proteins, such as membrane-associated guanylate kinases (MAGUKs) and scaffold proteins. This interference can lead to changes in the organization and stabilization of cellular junctions, as Lin-7b is essential for maintaining the polarization of epithelial cells and the proper function of synaptic structures. Inhibitors of Lin-7Bb are generally designed to alter these critical interactions, which can have downstream effects on cellular processes related to cell adhesion and signaling.
Structurally, Lin-7Bb inhibitors typically feature molecular motifs capable of interacting with the PDZ (Postsynaptic Density 95, Discs Large, Zonula Occludens-1) domain of the Lin-7b protein. These domains are important for recognizing and binding specific sequences in target proteins. By occupying these binding sites, Lin-7Bb inhibitors prevent Lin-7b from forming proper complexes with its partners. The design of these inhibitors often relies on understanding the three-dimensional conformation of Lin-7b and its binding interfaces. Inhibition can also be fine-tuned to be highly selective, reducing off-target interactions with other PDZ-containing proteins. This specificity is essential for studying the functional role of Lin-7b in different cellular contexts, allowing researchers to dissect its contributions to various signaling and structural pathways in cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound inhibits DNA methyltransferases, leading to hypomethylation of the LIN7B gene promoter, which could result in decreased transcription and subsequent downregulation of Lin-7Bb protein synthesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can hyperacetylate histones, causing chromatin expansion and potentially reducing the transcriptional activity of the LIN7B gene, leading to diminished Lin-7Bb expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin binds to mTOR and inhibits its activity, which can lead to a general decrease in protein synthesis, including the potential reduction in Lin-7Bb protein levels due to diminished translational activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 blocks PI3K activity, which may lead to a decrease in AKT phosphorylation and activity, potentially resulting in the decreased expression of Lin-7Bb if its expression is dependent on the PI3K/AKT pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK inhibitor that can decrease ERK phosphorylation, potentially leading to diminished transcriptional activity of genes downstream of the MAPK pathway, including possibly the LIN7B gene. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 inhibits TGF-β receptor activity, which could lead to reduced transcriptional activity of multiple genes, potentially including LIN7B, leading to lower levels of Lin-7Bb expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib inhibits the proteasome, preventing the degradation of ubiquitinated proteins, which could result in cellular stress and a subsequent decrease in the overall protein synthesis, including Lin-7Bb. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA, inhibiting RNA polymerase action, which can lead to a broad decrease in mRNA synthesis, potentially diminishing Lin-7Bb protein production due to reduced mRNA availability. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic ribosomes, leading to an inhibition of protein elongation, which would reduce the synthesis of all proteins, including Lin-7Bb, resulting in lower protein levels. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an inhibitor of MEK, which could lead to reduced phosphorylation of ERK in the MAPK pathway, potentially decreasing the transcription of genes that are regulated by this pathway, such as LIN7B. | ||||||