LCE3A Inhibitors
LCE3A Inhibitors encompass a diverse set of chemical compounds that modulate specific cellular signaling pathways, resulting in the downregulation or suppression of LCE3A activity. Compounds like curcumin, capsaicin, sulforaphane, epigallocatechin gallate, and withaferin A exert their inhibitory effects through the attenuation of the NF-kB pathway, a known regulator of LCE3A expression. By blocking the phosphorylation and degradation of IkB, these inhibitors prevent the translocation of NF-kB to the nucleus, thereby diminishing LCE3A transcription. Additionally, emodin and silybin serve as inhibitors by targeting the PI3K/Akt and STAT3 pathways, respectively, both of which may influence the expression levels of LCE3A through their roles in gene regulation. Emodin achieves this by hindering the PI3K/Akt signaling cascade, potentially leading to reduced LCE3A transcription, while Silybin suppresses STAT3 phosphorylation, which could result in decreased LCE3A expression if it falls under STAT3's regulatory purview.
Further contributing to the spectrum of LCE3A inhibitors, apigenin, quercetin, and kaempferol function through the inhibition of the JNK pathway and various kinases that are likely involved in LCE3A gene regulation. Apigenin's specific blockade of JNK signaling could lower the expression of stress-responsive genes such as LCE3A. Quercetin and kaempferol, both flavonoids, inhibit kinase phosphorylation, potentially affecting LCE3A expression if it is dependent on these kinase-regulated pathways. Indirubin adds to this inhibitory profile by disrupting CDKs and GSK-3β signaling, which could lead to a cascade of transcriptional changes resulting in reduced LCE3A expression. Collectively, these LCE3A inhibitors operate through distinct but converging mechanisms, all culminating in the downregulation of LCE3A without directly affecting its transcription or translation, but rather by altering the signaling pathways that control its expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to inhibit the NF-kB pathway by blocking the phosphorylation and degradation of IkB. Since the LCE3A gene is upregulated by NF-kB, curcumin's inhibitory effect on NF-kB would lead to decreased LCE3A expression. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Emodin can inhibit the PI3K/Akt pathway, which is involved in the transcriptional regulation of many genes. By inhibiting this pathway, emodin can indirectly decrease the expression of LCE3A, which is potentially regulated by PI3K/Akt. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been found to inhibit STAT3 signaling. Since STAT3 can modulate the expression of various genes, the inhibition of STAT3 by resveratrol could lead to a reduction in LCE3A expression if it is a STAT3-regulated gene. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin inhibits the JNK pathway, which can regulate gene expression in response to stress. By inhibiting JNK signaling, apigenin may decrease the expression of stress-responsive genes like LCE3A. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can inhibit the phosphorylation of various kinases. If LCE3A expression is regulated by kinases that are sensitive to quercetin, its expression could be diminished. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is known to activate the Nrf2 pathway, which can lead to the inhibition of NF-kB. As NF-kB could potentially regulate LCE3A expression, sulforaphane may indirectly diminish LCE3A levels by inhibiting NF-kB. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $114.00 $525.00 | 4 | |
Indirubin inhibits CDKs and GSK-3ß, which are part of signaling pathways that regulate cell cycle and gene expression. By inhibiting these kinases, indirubin could indirectly decrease the expression of proteins like LCE3A. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin can inhibit NF-kB activation. Since LCE3A gene expression could be modulated by NF-kB, capsaicin's effect on NF-kB might lead to a reduction in LCE3A expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This catechin inhibits several protein kinases and has been shown to inhibit NF-kB. By doing so, epigallocatechin gallate could indirectly lead to decreased LCE3A expression if LCE3A is a target of NF-kB-regulated transcription. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol inhibits the phosphorylation of various signaling proteins. By affecting these kinases, kaempferol could indirectly lead to a decrease in the expression of proteins like LCE3A if they are regulated by these kinases. | ||||||