Molecular structure of Indirubin, CAS Number: 479-41-4
Indirubin (CAS 479-41-4)
See product citations (4)
Alternate Names:
Isoindogotin; Indigo Red
Application:
Indirubin is an inhibitor of GSK-3β and cyclin-dependent kinases
CAS Number:
479-41-4
Purity:
≥97%
Molecular Weight:
262.26
Molecular Formula:
C16H10N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Indirubin is a natural compound that is extensively studied in the field of cell biology and biochemistry for its kinase inhibitory activity. It is particularly recognized for its ability to inhibit cyclin-dependent kinases (CDKs), which are integral to cell cycle regulation. Research utilizing indirubin often focuses on the mechanisms that control cell proliferation and the timing of cell cycle transitions. Moreover, indirubin is of interest in studies investigating the regulatory processes of neuronal cells and potential signaling pathways that influence neurogenesis. The compound′s diverse biological activities make it useful for researchers attempting to dissect complex cellular processes and the molecular basis of cell cycle control.
Indirubin (CAS 479-41-4) References
- Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? | Leclerc, S., et al. 2001. J Biol Chem. 276: 251-60. PMID: 11013232
- Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. | Adachi, J., et al. 2001. J Biol Chem. 276: 31475-8. PMID: 11425848
- Synthesis and evaluation of functionalized isoindigos as antiproliferative agents. | Wee, XK., et al. 2009. Bioorg Med Chem. 17: 7562-71. PMID: 19783149
- Synthesis of isoindigo-based oligothiophenes for molecular bulk heterojunction solar cells. | Mei, J., et al. 2010. Org Lett. 12: 660-3. PMID: 20099892
- Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways. | Lai, JL., et al. 2017. Inflammation. 40: 1-12. PMID: 27718095
- Indirubin-pregnane X receptor-JNK axis accelerates skin wound healing. | Tanaka, Y., et al. 2019. Sci Rep. 9: 18174. PMID: 31796845
- Indirubin inhibits Wnt/β-catenin signal pathway via promoter demethylation of WIF-1. | Liu, SG., et al. 2020. BMC Complement Med Ther. 20: 250. PMID: 32795328
- Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation. | Wang, Q., et al. 2020. Biomed Pharmacother. 131: 110715. PMID: 32927253
- Indirubin attenuates IL-17A-induced CCL20 expression and production in keratinocytes through repressing TAK1 signaling pathway. | Zhao, J., et al. 2021. Int Immunopharmacol. 94: 107229. PMID: 33611057
- Indirubin-3'-alkoxime derivatives for upregulation of Wnt signaling through dual inhibition of GSK-3β and the CXXC5-Dvl interaction. | Song, D., et al. 2022. Bioorg Chem. 121: 105664. PMID: 35176556
- [Indirubin relieves inflammatory injury of chondrocytes in a mouse model of osteoarthritis]. | Chen, X., et al. 2022. Nan Fang Yi Ke Da Xue Xue Bao. 42: 1381-1388. PMID: 36210712
- Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice. | Lu, X., et al. 2022. Front Immunol. 13: 1033498. PMID: 36466901
- [Potential antileukemic agents, synthesis of derivatives of indirubin, indigo, and isoindigotin]. | Wu, KM., et al. 1985. Yao Xue Xue Bao. 20: 821-6. PMID: 3869774
Inhibitor of:
14-3-3 ζ, ADCK4, ALP, BBS2, BEND6, BPV E2, BST-2, C-Nap1, C11orf60, C2orf30, C6orf1, casein kinase IIβ, Cdc2, Cdk11, Cdk2, Cdk4, Cdk5, Cks2, CLK1, cyclin A, cyclin B, cyclin C, cyclin D1, cyclin E, Dyrk1A, FAM111B, FLJ32549, GRK 5, GRK 7, GSKIP, HEXIM1, HPV16 E2, IL-20, IL-TIFb, ISGF-3γ p48, KRTAP13, KRTAP5-11, LAGE-3, LCE3A, LCE3B, LOC341346, MCEMP1, MIPU1, MUSTN1, Naglt1a, p35, p53CSV, PRC1, PROX1, Psoriasin, Repetin, RYK, SIK1, Sprr2a2, TAF II p105, THEG, and UTF1.Activator of:
AF-10, Axin, BMP-3b, C/EBP α, C19orf71, Cdk7, Ciao 1, CLK3, E2F-3, GIPC3, Lce1k, LOC100041261, LRRC61, MAZ, p35, PIAS 1, Pin1, S100A7A, Smad1, VWC2L, WRM-1, and ZBTB7C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Indirubin, 5 mg | sc-201531 | 5 mg | $112.00 | |||
Indirubin, 25 mg | sc-201531A | 25 mg | $515.00 |