Laminin γ-3 Inhibitors
Laminin γ-3 inhibitors are compounds designed to specifically target the gamma-3 chain of laminins, which are essential glycoproteins in the extracellular matrix. Laminins are heterotrimeric proteins composed of alpha, beta, and gamma chains, and the gamma-3 chain is predominantly expressed in neural tissues. This chain plays a crucial role in neural development, influencing processes such as cell adhesion, migration, and differentiation. By inhibiting Laminin γ-3, these compounds can modulate the interactions between cells and the extracellular matrix, providing a means to study the specific functions of the gamma-3 chain in neural tissues.
The development of Laminin γ-3 inhibitors involves designing molecules that can bind selectively to the gamma-3 chain, disrupting its interaction with cellular receptors or other extracellular matrix components. Techniques such as structure-based design and high-throughput screening are employed to identify compounds with high specificity and affinity for Laminin γ-3. Understanding the structure-activity relationships of these inhibitors is essential for optimizing their potency and selectivity. Research into Laminin γ-3 inhibitors contributes to a deeper understanding of extracellular matrix biology and the molecular mechanisms governing neural development and function. These inhibitors serve as valuable tools for dissecting the role of Laminin γ-3 in various cellular processes and for exploring the complex dynamics of cell-matrix interactions in neural tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Integrin inhibitors can disrupt cell-matrix interactions, potentially affecting Laminin γ-3 mediated adhesion. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
MMP inhibitors prevent extracellular matrix degradation, possibly influencing Laminin γ-3 turnover. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
TGF-β inhibitors can modulate extracellular matrix production, potentially affecting Laminin γ-3 expression. | ||||||
Ammonium tetrathiomolybdate | 15060-55-6 | sc-239242 sc-239242A sc-239242B sc-239242C | 1 g 10 g 25 g 50 g | $47.00 $203.00 $421.00 $525.00 | ||
Copper is essential for certain enzymes that modulate the extracellular matrix; its chelation might affect Laminin γ-3. | ||||||
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $104.00 | ||
Lysyl oxidase inhibitors can disrupt collagen and elastin crosslinking, potentially affecting Laminin γ-3's extracellular matrix interactions. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
As a copper chelator, D-Penicillamine might affect enzymes crucial for extracellular matrix maintenance, indirectly influencing Laminin γ-3. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Another MMP inhibitor, GM6001, may indirectly influence the stability and turnover of Laminin γ-3. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat is a broad-spectrum MMP inhibitor, which might affect Laminin γ-3 by altering extracellular matrix dynamics. | ||||||
(3-Aminopropyl)triethoxysilane | 919-30-2 | sc-238493 | 250 ml | $66.00 | 3 | |
APTES affects cell adhesion to surfaces, which might indirectly influence Laminin γ-3 mediated interactions. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
PDGF inhibitors can modulate cell signaling related to extracellular matrix production, potentially affecting Laminin γ-3. | ||||||