Laminin γ-3 Antibody (2#): sc-517444

Laminin γ-3 Antibody (2#) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Laminin gamma-3 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Laminin gamma-3 antibody (2#) is available as a non-conjugated format. Laminins, including Laminin gamma-3, are crucial structural components of basement membranes, which are specialized extracellular matrices that provide support and anchorage for cells. The unique structure of Laminins, composed of three polypeptide chains (α, β, and γ), allows them to form a network that interacts with various cell types through specific receptors, such as integrins and dystroglycan. This interaction is vital for maintaining tissue integrity and facilitating cellular processes such as migration, proliferation, and differentiation. Laminin gamma-3 is particularly important in the formation of basement membranes found beneath epithelial layers and surrounding muscle and nerve cells, influencing not only the structural organization of tissues but also their functional properties. The human Laminin γ-3 gene is located on chromosome 9q34.12 and plays a significant role in the development and maintenance of ciliated epithelial cells in various organs, including the lungs and reproductive tract.

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Laminin γ-3 Antibody (2#) References:

1. Role of laminin isoforms in glomerular structure.  |  Hansen, K. and Abrass, CK. 1999. Pathobiology. 67: 84-91. PMID: 10023136
2. Form and function: the laminin family of heterotrimers.  |  Colognato, H. and Yurchenco, PD. 2000. Dev Dyn. 218: 213-34. PMID: 10842354
3. Transcriptional regulation of laminin gene expression.  |  Aberdam, D., et al. 2000. Microsc Res Tech. 51: 228-37. PMID: 11054873
4. The laminin family.  |  Tryggvason, K. 1993. Curr Opin Cell Biol. 5: 877-82. PMID: 8240830
5. Role of laminin in endothelial cell recognition and differentiation.  |  Schnaper, HW., et al. 1993. Kidney Int. 43: 20-5. PMID: 8433560
6. Domains of laminin.  |  Engvall, E. and Wewer, UM. 1996. J Cell Biochem. 61: 493-501. PMID: 8806072
7. Laminin and the mechanism of neuronal outgrowth.  |  Luckenbill-Edds, L. 1997. Brain Res Brain Res Rev. 23: 1-27. PMID: 9063584
8. Laminin isoforms and epithelial development.  |  Ekblom, M., et al. 1998. Ann N Y Acad Sci. 857: 194-211. PMID: 9917842

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Laminin γ-3 Antibody (2#) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Laminin γ-3 Antibody (2#) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Laminin γ-3 Antibody (2#) Specifications

Alternate Product Name: Laminin γ-3

Product Clone Name: 2#

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1250-1418

Epitope Target: Laminin γ-3

Epitope Species: mouse

Product Reactivity/Detection: Laminin γ-3

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Laminin γ-3 Antibody (2#): N/A