Laminin α-2 Inhibitors
Laminin α-2 inhibitors belong to a specialized class of chemical compounds designed to target and interact with the laminin α-2 protein. Laminins are a family of high-molecular-weight glycoproteins that are crucial components of the extracellular matrix (ECM), a complex network of proteins and carbohydrates surrounding cells. Laminin α-2, in particular, plays a pivotal role in forming the structural framework of tissues, especially in muscle cells and peripheral nerves. It is primarily known for its role in the development and maintenance of skeletal muscles and the peripheral nervous system. Laminin α-2 inhibitors are engineered to specifically interfere with the function of this laminin isoform, offering a means to modulate cellular processes associated with its activity.
The primary mechanism of action of laminin α-2 inhibitors involves binding to laminin α-2, thereby disrupting its interactions with other ECM components, cell surface receptors, or signaling molecules. By doing so, these inhibitors can influence various cellular processes, such as adhesion, migration, and differentiation, which are essential for the proper development and functioning of muscle tissues and peripheral nerves. Additionally, these inhibitors may find applications in research aimed at understanding the molecular basis of diseases related to laminin α-2 dysregulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-azacytidine can induce demethylation, leading to changes in gene expression. This may impact the transcriptional regulation of proteins like Laminin α-2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can affect chromatin structure and gene expression. This has the potential to modulate the expression of various proteins, possibly including Laminin α-2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is involved in cell growth and protein synthesis. This inhibition can impact the expression of several proteins, potentially including Laminin α-2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to modulate various signaling pathways and affect gene expression. Its potential impact on Laminin α-2 expression may be due to its anti-inflammatory and antioxidant properties. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine Sulfate can affect lysosomal function and autophagy, potentially leading to alterations in protein expression and cellular homeostasis. This might influence the expression levels of Laminin α-2. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
As a kinase inhibitor, Sorafenib can interfere with signal transduction pathways, potentially leading to changes in protein expression. This could affect the regulation of Laminin α-2 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to influence gene expression through various mechanisms. Its potential impact on Laminin α-2 expression may be linked to its antioxidative and anti-inflammatory properties. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can modulate signal transduction pathways and affect gene expression. Its potential role in inhibiting Laminin α-2 expression may be related to its anti-inflammatory and antioxidant effects. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride influences various signaling pathways, including Wnt and GSK-3β, potentially affecting gene expression and cellular processes. This might impact the regulation of Laminin α-2. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride activates AMPK, influencing cellular energy status and metabolic pathways. This can lead to changes in protein expression, potentially impacting Laminin α-2. | ||||||