KLHL12 Activators
KLHL12 Activators are chemicals that can increase the functional activity of KLHL12, a protein that plays a vital role in the ubiquitination of G proteins and is involved in cAMP signaling and Protein Kinase C (PKC) pathway. Compounds like Forskolin, a potent adenylate cyclase activator, and Rolipram, a selective phosphodiesterase-4 inhibitor, enhance cAMP production, indirectly increasing the interaction of KLHL12 with its G protein substrates. Similarly, IBMX, another phosphodiesterase inhibitor, and ZM241385, an antagonist of the adenosine A2A receptor, work by enhancing cAMP levels, which in turn facilitates KLHL12's functional activity. Furthermore, SQ22536, an adenylate cyclase inhibitor, and KT5720, a selective inhibitor of Protein Kinase A (PKA), modulate cAMP levels, thereby indirectly augmenting the functional activity of KLHL12.
In addition, several KLHL12 activatorsinteract with the Protein Kinase C (PKC) pathway, which is known to enhance the phosphorylation and activation of KLHL12. PMA, a potent activator of PKC, and Go6976 and BIM I, both selective PKC inhibitors, can indirectly increase the demand for KLHL12's role in the PKC pathway, thereby enhancing its functional activity. Moreover, Oxotremorine-M, Atropine and Pilocarpine are muscarinic acetylcholine receptor (mAChR) agonists or antagonists that can enhance the phosphorylation and activation of KLHL12. The activation of mAChR can lead to an increased demand for KLHL12's role in this pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent adenylate cyclase activator that enhances cAMP production. KLHL12 is known to interact with and ubiquitinate G proteins, which are regulated by cAMP. Therefore, increasing cAMP levels can enhance the functional activity of KLHL12 through increased interaction with its G protein substrates. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor which increases cellular cAMP levels. As KLHL12 interacts with and ubiquitinates G proteins that are regulated by cAMP, the increase in cAMP levels can enhance the functional activity of KLHL12. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific phosphodiesterase inhibitor that raises intracellular cAMP levels. By raising cAMP levels, IBMX enhances the functional activity of KLHL12 by increasing its interaction with G proteins that are regulated by cAMP. | ||||||
ZM 241385 | 139180-30-6 | sc-361421 sc-361421A | 5 mg 25 mg | $92.00 $356.00 | 1 | |
ZM241385 is an antagonist of the adenosine A2A receptor. The adenosine A2A receptor negatively regulates adenylate cyclase activity and cAMP production. By blocking this receptor, ZM241385 can enhance cAMP production, indirectly enhancing the functional activity of KLHL12. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
SQ22536 is an adenylate cyclase inhibitor. By inhibiting adenylate cyclase, SQ22536 enhances cAMP production, indirectly enhancing the functional activity of KLHL12 which interacts with and ubiquitinates G proteins regulated by cAMP. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $138.00 $220.00 $972.00 | 47 | |
KT5720 is a selective inhibitor of Protein Kinase A (PKA), an enzyme activated by cAMP. By inhibiting PKA, KT5720 enhances the amount of cAMP available for other cAMP-dependent processes, indirectly enhancing the functional activity of KLHL12. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). Activation of PKC can enhance the phosphorylation and activation of KLHL12, enhancing its functional activity. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Go6976 is a selective PKC inhibitor. PKC activation can lead to phosphorylation and activation of KLHL12. By inhibiting PKC, Go6976 can indirectly enhance the activity of KLHL12 by increasing demand for its role in this pathway. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
BIM I is a specific inhibitor of PKC. By inhibiting PKC, BIM I can indirectly enhance the activity of KLHL12 by increasing the demand for its role in the PKC pathway. | ||||||
Oxotremorine M | 63939-65-1 | sc-203656 | 100 mg | $148.00 | 3 | |
Oxotremorine-M is a muscarinic acetylcholine receptor (mAChR) agonist. Activation of mAChR can enhance the phosphorylation and activation of KLHL12, enhancing its functional activity. | ||||||