KIR2DS4 Activators
KIR2DS4 activators are chemicals that can increase the functional activity of KIR2DS4, a protein that plays a significant role in the activation of natural killer cells. These activators work by interacting with specific signaling pathways that KIR2DS4 is involved in, such as the Syk kinase pathway, Src-family kinases, and the Bcr-Abl tyrosine kinase. For instance, Piceatannol is a potent Syk kinase inhibitor that enhances KIR2DS4 activity by increasing the demand for KIR2DS4 in the Syk kinase pathway. Similarly, Imatinib, a selective inhibitor of Bcr-Abl tyrosine kinase, can enhance the functional activity of KIR2DS4 by increasing the need for KIR2DS4 in their respective pathways.
KIR2DS4 activators also include inhibitors of the JAK-STAT pathway, the PI3K pathway, and the MAPK pathway, all of which are known to involve KIR2DS4. ZM 449829 and WHI-P154 are JAK3 inhibitors that can enhance KIR2DS4 activity by increasing the demand for KIR2DS4 in the JAK-STAT pathway. AG-490 and TG101348, both JAK2 inhibitors, work in a similar manner. In the PI3K pathway, LY294002 and Quercetin, both PI3K inhibitors, can enhance the functional activity of KIR2DS4 by increasing the need for KIR2DS4. Lastly, SB203580, a p38 MAPK inhibitor, can enhance KIR2DS4 activity by increasing the demand for KIR2DS4 in the MAPK pathway. These chemicals thus serve as specific activators of KIR2DS4, directly or indirectly enhancing its functional activity by interacting with the specific signaling pathways or biological processes that KIR2DS4 is directly involved in.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol is a potent Syk kinase inhibitor. KIR2DS4 activates natural killer (NK) cells through the Syk kinase pathway. By inhibiting this pathway, Piceatannol can increase the demand for KIR2DS4, enhancing its functional activity. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a selective inhibitor of Bcr-Abl tyrosine kinase. KIR2DS4 is known to inhibit NK cell function via ITIM motifs, which can lead to an increase in tyrosine kinase activity. By inhibiting this kinase, Imatinib can enhance the activating effect of KIR2DS4 on NK cells. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR tyrosine kinase inhibitor. KIR2DS4 can enhance NK cell activation and the inhibition of EGFR can increase the demand for KIR2DS4, enhancing its functional activity. | ||||||
WHI-P 154 | 211555-04-3 | sc-204395 sc-204395A | 10 mg 50 mg | $150.00 $630.00 | 3 | |
WHI-P154 is a JAK3 inhibitor. By inhibiting JAK3, it can enhance the need for KIR2DS4 in the activation of the JAK-STAT pathway in NK cells. | ||||||
R406 | 841290-81-1 | sc-364595 sc-364595A | 2 mg 10 mg | $160.00 $370.00 | 16 | |
R406 is a Syk inhibitor. By inhibiting Syk, R406 can enhance the functional activity of KIR2DS4 in NK cell activation. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG-490 is a JAK2 inhibitor. By inhibiting JAK2, it can increase the demand for KIR2DS4 in the JAK-STAT pathway, indirectly enhancing its activity. | ||||||
TG101348 | 936091-26-8 | sc-364740 sc-364740A | 5 mg 25 mg | $207.00 $515.00 | 6 | |
TG101348 is a JAK2 inhibitor. By inhibiting JAK2, it can increase the demand for KIR2DS4 in the JAK-STAT pathway, indirectly enhancing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. KIR2DS4 is known to activate NK cells through the PI3K pathway. By inhibiting this pathway, LY294002 can increase the need for KIR2DS4, indirectly enhancing its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. KIR2DS4 is known to activate NK cells through the MAPK pathway. By inhibiting this pathway, SB203580 can increase the need for KIR2DS4, indirectly enhancing its activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a PI3K inhibitor. By inhibiting PI3K, Quercetin can enhance the need for KIR2DS4 in the activation of the PI3K pathway in NK cells. | ||||||