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R406 is an inhibitor of IgE and IgG-mediated activation of Fc receptor signaling, stopping the production/release of LTC4, cytokines, and chemokines, including TNFα, IL-8, and GM-CSF. R406 inhibits phosphorylation of Syk substrate linker and blocks Syk-dependent T-cell and B-cell activation. R406 significantly induces chronic lymphocytic leukemia (CLL) cell apoptosis in nurse-like cell co-cultures and blocks CCL3 and CCL4 secretion by CLL cells in response to B-cell antigen receptor (Bcr) triggering. R406 is a potent inhibitor of platelet signaling and Flt-3/Flk-2.
See how others have used R406. Click on the entry to view the PubMed entry .
PMID: # 31197205 Wang, WG.|Jiang, XN.|Sheng, D.|Sun, CB.|Lee, J.|Zhou, XY.|Li, XQ.| et al. 2019. Lab. Invest.
PMID: # 31340154 Ziegler, CGK.|Kim, J.|Piersanti, K.|Oyler-Yaniv, A.|Argyropoulos, KV.|van den Brink, MRM.|Palomba, ML.|Altan-Bonnet, N.|Altan-Bonnet, G.| et al. 2019. Cell Rep. 28: 923-937.e3.
PMID: # 29728446 Hayashi, H.|Kaneko, R.|Demizu, S.|Akasaka, D.|Tayama, M.|Harada, T.|Irie, H.|Ogino, Y.|Fujino, N.|Sasaki, E.| et al. 2018. J. Pharmacol. Exp. Ther. 366: 84-95.
PMID: # 29868018 Dagher, Z.|Xu, S.|Negoro, PE.|Khan, NS.|Feldman, MB.|Reedy, JL.|Tam, JM.|Sykes, DB.|Mansour, MK.| et al. 2018. Front Immunol. 9: 1058.
PMID: # 28639315 Wang, WG.|Liu, ZB.|Jiang, XN.|Lee, J.|Zhou, XY.|Li, XQ.| et al. 2017. Histopathology. 71: 778-785.
PMID: # 27294852 Agustinho, DP. et al. 2016. Virulence. 0.
PMID: # 26829985 Khan, NS. et al. 2016. J. Immunol. 196: 2249-61.
PMID: # 25970684 Wang, WG. et al. 2015. The American journal of surgical pathology. 39: 902-11.
PMID: # 26032420 Callaway, JB. et al. 2015. The Journal of biological chemistry. 290: 17306-20.
PMID: # 26032420 Callaway, JB. et al. 2015. J. Biol. Chem. 290: 17306-20.
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