WHI-P 154 (CAS 211555-04-3)

WHI-P 154 is a synthetic compound recognized for its role as a potent inhibitor of Janus kinases (JAKs), specifically targeting JAK3. This chemical exerts its effects by interfering with the ATP-binding site of the kinase, effectively blocking its enzymatic activity. Janus kinases are integral to the signaling pathways of various cytokines and growth factors, primarily involved in processes such as cell growth, survival, development, and differentiation. WHI-P 154′s mechanism of action involves the inhibition of JAK3, which disrupts the JAK-STAT signaling pathway, a critical pathway for the transduction of extracellular signals into the cell nucleus to modulate gene expression. By inhibiting this pathway, WHI-P 154 effectively reduces the transcriptional activation typically mediated by STAT proteins, thus impacting cellular responses to external signals. WHI-P 154 has been utilized to investigate the role of JAK-STAT signaling in various biological contexts. It has been particularly useful in studies focused on immunology and hematopoiesis, where JAK-STAT pathway plays a predominant role. By using this inhibitor, scientists can explore the effects of altered JAK-STAT signaling on immune cell function and development, contributing to a deeper understanding of immune regulation and the underlying mechanisms that control cellular responses to cytokines.