KIR2DL3 Activators
KIR2DL3 Activators are a group of varied chemical compounds that can enhance the functional activity of KIR2DL3, a protein that plays a role in the regulation of natural killer cell function. These activators work indirectly, influencing various intracellular signaling pathways to upregulate KIR2DL3 activity. For instance, compounds like PMA can activate PKC, which phosphorylates ITIMs in KIR2DL3, leading to enhanced inhibitory signaling. Similarly, ionomycin and thapsigargin increase intracellular calcium levels, activating the calcineurin-NFAT pathway and increasing KIR2DL3 function.
On the other hand, compounds like cyclosporin A, FK506, and nifedipine work by decreasing intracellular calcium levels or inhibiting calcineurin, thereby affecting the calcineurin-NFAT pathway and enhancing KIR2DL3 function. Rapamycin, an mTOR inhibitor, reduces cell proliferation, leading to an increase in KIR2DL3 function. H89, a potent PKA inhibitor, shifts the balance of intracellular signaling towards PKC, boosting KIR2DL3 function. PD0325901 and SB203580, inhibitors of MEK and p38 MAPK respectively, affect the ERK/MAPK and p38/MAPK pathways, leading to increased KIR2DL3 function. Lastly, BAPTA-AM, a cell-permeable calcium chelator, by reducing intracellular calcium levels, can influence the calcineurin-NFAT pathway and enhance KIR2DL3 function. In each case, these activators are indirectly manipulating cellular processes to increase the functional activity of KIR2DL3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). Activated PKC can phosphorylate ITIMs in KIR2DL3, leading to the recruitment of SHP-1 and SHP-2 phosphatases, which can enhance inhibitory signaling of KIR2DL3. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that can increase intracellular calcium levels. Elevated calcium levels can activate calcineurin, which can dephosphorylate NFAT, leading to its nuclear translocation and increased expression of KIR2DL3. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin leads to an increase in intracellular calcium levels by inhibiting the SERCA calcium pump in the endoplasmic reticulum. The resulting elevation in calcium levels can activate the calcineurin-NFAT pathway, potentially enhancing KIR2DL3 function. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits calcineurin, indirectly leading to decreased NFAT dephosphorylation and nuclear translocation. This can result in a relative increase in KIR2DL3 expression and function. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 binds to FKBP and inhibits calcineurin, leading to decreased NFAT dephosphorylation and nuclear translocation. This can result in a relative increase in KIR2DL3 expression and function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a downstream effector of the PI3K/AKT pathway, thereby reducing cell proliferation and leading to an increase in KIR2DL3 function. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that can decrease intracellular calcium levels, thereby influencing the calcineurin-NFAT pathway and potentially enhancing KIR2DL3 function. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is another calcium channel blocker that could decrease intracellular calcium levels, potentially influencing the calcineurin-NFAT pathway and enhancing KIR2DL3 function. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a potent PKA inhibitor. By inhibiting PKA, it can shift the balance of intracellular signaling towards PKC, potentially enhancing the function of KIR2DL3. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a p38 MAPK inhibitor. By inhibiting p38, it affects the p38/MAPK pathway, which can lead to an increase in KIR2DL3 function. | ||||||