KIR2DL3 Antibody (E-5): sc-398606
- KIR2DL3 Antibody (E-5) is a mouse monoclonal IgG2b κ KIR2DL3 antibody provided at 200 µg/ml
- raised against amino acids 260-303 mapping within an internal region of KIR2DL3 of human origin
- KIR2DL3 Antibody (E-5) is recommended for detection of KIR2DL3, KIR2DS3 and KIR3DL3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-KIR2DL3 Antibody (E-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KIR2DL3 Antibody (E-5) for WB applications. These reagents are now offered in bundles with KIR2DL3 Antibody (E-5) (see ordering information below).
KIR2DL3 Antibody (E-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects KIR2DL3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KIR2DL3 (E-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KIR2DL3 plays a crucial role in the immune system as an inhibitory receptor that interacts specifically with the human MHC class I molecule HLA-Cw3 and related alleles, thereby modulating the activity of natural killer (NK) cells. By downregulating NK cell cytotoxicity upon recognition of these MHC molecules on target cells, KIR2DL3 helps maintain immune tolerance and prevent autoimmunity, which is vital for the body′s ability to distinguish between self and non-self. The KIR family, including KIR2DL3, is characterized by an extracellular region containing immunoglobulin-like domains and a cytoplasmic domain with an immunoreceptor tyrosine-based inhibitory motif (ITIM), which is essential for transmitting inhibitory signals within NK cells. This intricate signaling mechanism underscores the importance of KIR2DL3 in regulating immune responses and highlights its potential as a target for therapeutic interventions in diseases where NK cell activity is dysregulated.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KIR2DL3 Antibody (E-5) References:
- Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I. | Maenaka, K., et al. 1999. Structure. 7: 391-8. PMID: 10196125
- Modulation of T-cell functions in KIR2DL3 (CD158b) transgenic mice. | Cambiaggi, A., et al. 1999. Blood. 94: 2396-402. PMID: 10498612
- Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters. | Moodie, SJ., et al. 2002. Eur J Immunogenet. 29: 287-91. PMID: 12121272
- Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes. | Uhrberg, M., et al. 2002. Immunogenetics. 54: 221-9. PMID: 12136333
- Investigation of killer cell immunoglobulin-like receptor gene diversity III. KIR2DL3. | Keaney, L., et al. 2004. Tissue Antigens. 64: 188-94. PMID: 15245374
- Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2. | Vitale, M., et al. 2004. Int Immunol. 16: 1459-66. PMID: 15314042
- Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3. | Trompeter, HI., et al. 2005. J Immunol. 174: 4135-43. PMID: 15778373
- HLA-C and KIR genes in hepatitis C virus infection. | Montes-Cano, MA., et al. 2005. Hum Immunol. 66: 1106-9. PMID: 16571411
- Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility. | Jones, DC., et al. 2006. Genes Immun. 7: 576-82. PMID: 16929347
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIR2DL3 Antibody (E-5) | sc-398606 | 200 µg/ml | $322.00 | |||
KIR2DL3 Antibody (E-5): m-IgG Fc BP-HRP Bundle | sc-530869 | 200 µg Ab; 10 µg BP | $361.00 | |||
KIR2DL3 Antibody (E-5): m-IgGκ BP-HRP Bundle | sc-524418 | 200 µg Ab, 40 µg BP | $361.00 | |||
KIR2DL3 Antibody (E-5) AC | sc-398606 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KIR2DL3 Antibody (E-5) HRP | sc-398606 HRP | 200 µg/ml | $322.00 | |||
KIR2DL3 Antibody (E-5) FITC | sc-398606 FITC | 200 µg/ml | $336.00 | |||
KIR2DL3 Antibody (E-5) PE | sc-398606 PE | 200 µg/ml | $349.00 | |||
KIR2DL3 Antibody (E-5) Alexa Fluor® 488 | sc-398606 AF488 | 200 µg/ml | $364.00 | |||
KIR2DL3 Antibody (E-5) Alexa Fluor® 546 | sc-398606 AF546 | 200 µg/ml | $364.00 | |||
KIR2DL3 Antibody (E-5) Alexa Fluor® 594 | sc-398606 AF594 | 200 µg/ml | $364.00 | |||
KIR2DL3 Antibody (E-5) Alexa Fluor® 647 | sc-398606 AF647 | 200 µg/ml | $364.00 | |||
KIR2DL3 Antibody (E-5) Alexa Fluor® 680 | sc-398606 AF680 | 200 µg/ml | $364.00 | |||
KIR2DL3 Antibody (E-5) Alexa Fluor® 790 | sc-398606 AF790 | 200 µg/ml | $364.00 |