KCTD8 Activators
KCTD8 activators are a class of chemical compounds that interact with a specific component of cellular machinery known as the KCTD8 protein. KCTD8, an acronym for Potassium Channel Tetramerization Domain containing 8, is a member of a larger family of proteins that are characterized by the presence of a tetramerization domain, a structural motif that facilitates the assembly of four subunits into a functional complex. These proteins are implicated in a variety of cellular processes due to their role in the modulation of potassium channels, which are critical for maintaining the electrical conductivity and signaling in cells. Activators of KCTD8 influence the protein's behavior by enhancing its functional activity, thereby affecting the associated biological pathways. The nature of the interaction between KCTD8 activators and the KCTD8 protein can vary, ranging from direct binding to indirect modulation via interaction with other molecular entities that regulate the protein's function.
The chemical scaffolds of KCTD8 activators are diverse, reflecting the complexity of modulating a protein that may interact with various cellular partners and pathways. The precise mechanism by which these activators exert their influence can include changes in the protein's conformation, stability, or its interaction with other proteins and cellular components. This modulation can alter the dynamics of potassium channel tetramerization and, consequently, the flow of potassium ions across the cellular membrane. Such a fundamental process has far-reaching implications for the maintenance of cellular homeostasis and the regulation of electrical signals. The discovery and development of KCTD8 activators are rooted in the principles of structural biology, fields that provide insights into how small molecules can interact with specific protein targets to modulate their activity. Research into KCTD8 activators typically involves a combination of in silico modeling, synthetic chemistry, and various biochemical assays to elucidate the compounds' mechanism of action and their interaction with the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene that acts as an activator of the enzyme adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) within the cell. Elevated cAMP may enhance the functional activity of KCTD8 if KCTD8 is involved in pathways that are regulated by cAMP signaling. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways. By mimicking cAMP, it could potentially enhance KCTD8 activity if KCTD8 is functionally regulated by cAMP-dependent signaling mechanisms. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic receptor agonist that elevates intracellular cAMP levels. This increase in cAMP may indirectly augment the activity of KCTD8 if KCTD8 is modulated by beta-adrenergic signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, IBMX could indirectly increase KCTD8 activity if KCTD8 is part of a pathway that is positively influenced by high cAMP levels. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). It may indirectly promote KCTD8 activity if KCTD8 is downstream of PKC in cellular signaling pathways or if PKC-mediated phosphorylation events modulate KCTD8 function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium may indirectly activate KCTD8 if KCTD8 is involved in calcium-dependent signaling pathways or if calcium binding alters KCTD8 function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that raises intracellular calcium levels. By enhancing calcium signaling, A23187 could indirectly enhance KCTD8 activity if KCTD8's function is modulated by calcium-dependent processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol compound with kinase inhibitory activity. It could indirectly enhance KCTD8 activity by inhibiting kinases that may negatively regulate KCTD8 or by modulating signaling pathways that intersect with KCTD8's functional role. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that may indirectly enhance KCTD8 activity by modulating the PI3K/AKT pathway, potentially affecting downstream proteins that interact with or regulate KCTD8. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is part of the MAPK pathway. By modulating this pathway, U0126 could potentially enhance KCTD8 activity if KCTD8 is functionally connected to the MAPK signaling cascade. | ||||||