JNK1 Inhibitors
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Items 1 to 10 of 13 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a widely used JNK inhibitor. It acts as an ATP-competitive inhibitor, targeting the active site of JNK1, preventing phosphorylation of downstream substrates. | ||||||
JNK Inhibitor VIII | 894804-07-0 | sc-202673 | 5 mg | $272.00 | 2 | |
JNK Inhibitor VIII is a potent and selective JNK inhibitor. It binds to the ATP-binding site of JNK1, blocking its kinase activity and impeding the activation of c-Jun transcription factor. | ||||||
JNK Inhibitor XVI | 1410880-22-6 | sc-364745 | 10 mg | $357.00 | 5 | |
JNK-IN-8 is a small molecule inhibitor of JNK1. It interferes with JNK-mediated signaling pathways by competitively inhibiting ATP binding to JNK1. | ||||||
JNK3 Inhibitor XII | 1164153-22-3 | sc-364742 | 5 mg | $165.00 | ||
JNK3 Inhibitor XII is a selective JNK1 inhibitor. It hampers JNK1 activation by competing for ATP binding, leading to the suppression of JNK-mediated signaling pathways. | ||||||
JNK Inhibitor V | 345987-15-7 | sc-202672A sc-202672 | 1 mg 5 mg | $60.00 $169.00 | 3 | |
AS601245 is an ATP-competitive inhibitor of JNK1. It prevents the phosphorylation of JNK substrates by binding to the active site of the kinase and inhibiting its activity. | ||||||
JNK Inhibitor XIV | sc-364744 | 10 mg | $379.00 | |||
JNK Inhibitor XIV operates by selectively binding to the ATP-binding pocket of JNK1, disrupting its phosphorylation activity. This competitive inhibition alters the enzyme's conformational dynamics, effectively modulating downstream signaling pathways. Its unique structural features facilitate strong interactions with key amino acid residues, enhancing specificity. Additionally, the compound's hydrophobic characteristics promote its stability in various environments, influencing its kinetic profile and interaction with cellular components. | ||||||
L-JNKi1 | 1445179-97-4 D-isomer | sc-300882 | 1 mg | $319.00 | ||
L-JNKi1 is a selective inhibitor of JNK1 that engages in unique molecular interactions, particularly through its ability to form hydrogen bonds with critical residues in the enzyme's active site. This interaction not only stabilizes the inhibitor-enzyme complex but also alters the enzyme's catalytic efficiency. The compound's distinct hydrophobic regions enhance its affinity for JNK1, influencing the kinetics of substrate binding and subsequent signal transduction pathways. | ||||||
BI 78D3 | 883065-90-5 | sc-203840 sc-203840A | 10 mg 50 mg | $204.00 $810.00 | 2 | |
BI-78D3 is a selective JNK inhibitor. It hinders JNK1 activation by interfering with ATP binding, ultimately suppressing c-Jun phosphorylation and downstream events. | ||||||
JNK Inhibitor XV | sc-364746 | 25 mg | $209.00 | |||
JNK Inhibitor XV is a highly selective JNK1 inhibitor characterized by its unique binding dynamics. It exhibits a strong affinity for the enzyme's active site, where it engages in van der Waals interactions and hydrophobic contacts that modulate enzyme conformation. This compound effectively disrupts JNK1-mediated signaling cascades, showcasing distinct reaction kinetics that influence downstream cellular responses. Its structural features contribute to a refined selectivity profile, enhancing its interaction specificity. | ||||||
p38 MAP Kinase Inhibitor IV | 1638-41-1 | sc-204159 | 5 mg | $295.00 | ||
p38 MAP Kinase Inhibitor IV is a potent inhibitor that selectively targets JNK1, demonstrating unique molecular interactions that stabilize the enzyme's inactive conformation. Its binding involves intricate hydrogen bonding and electrostatic interactions, which effectively hinder substrate access. The compound's kinetic profile reveals a slow-onset inhibition, allowing for prolonged modulation of JNK1 activity. This specificity is further enhanced by its unique structural motifs, which facilitate targeted engagement with the kinase. | ||||||