Molecular structure of BI 78D3, CAS Number: 883065-90-5
BI 78D3 (CAS 883065-90-5)
See product citations (2)
Application:
BI 78D3 is a competitive JNK (c-Jun N-terminal kinases) inhibitor
CAS Number:
883065-90-5
Purity:
>99%
Molecular Weight:
379.36
Molecular Formula:
C13H9N5O5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Restores insulin sensitivity in a mouse model of type II diabetes and blocks JNK-dependent Con A-induced liver damage.
BI 78D3 (CAS 883065-90-5) References
Stebbins et al (2008) Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc.Natl.Acad.Sci.USA 105 16809. Flight (2008) Getting rid of JNK. Nat.Rev.Drug Disc. 7. Haas and Writer (2008) Block JNK at the dock. SCiBX 1 1.Inhibitor of:
4931417E11Rik, C030048H21Rik, JIP-2, JIP-3, JNK, JNK1, JNK2, JNK3, MAP-9, MCAT, NTS12, Ser/Thr Protein Kinase, and SPEER-3.Activator of:
Akt1, ARFGAP1, Rabex-5, and RGS14.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BI 78D3, 10 mg | sc-203840 | 10 mg | $204.00 | |||
| US: Only available in the US | ||||||
BI 78D3, 50 mg | sc-203840A | 50 mg | $810.00 | |||
| US: Only available in the US | ||||||