L-JNKi1 (CAS 1445179-97-4 D-isomer)
Alternate Names:
JNK inhibitor 1 (L-stereoisomer); c-Jun N-terminal kinase peptide inhibitor 1; L-stereoisomer
CAS Number:
1445179-97-4 D-isomer
Purity:
≥95%
Molecular Weight:
3822.5
Molecular Formula:
C164H286N66O40
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-JNKi1 is a protease resistant, potent inhibitor specific for JNK (JNK1, JNK2 and JNK3). L-JNKi 1 does not directly affect kinase activity e.g. by competing with the ATP-binding site of the protein kinase, rather L-JNKi1 inhibits the interaction between JNK and its substrate, resulting in a JNK K.O. phenotype. In contrast to pure diffusion they are actively transported into cells, where they remain until their proteolytic degradation. The c-Jun N-terminal kinases (JNK1, 2, 3), members of the mitogen-activated protein kinase (MAPK) superfamily, are activated by a wide variety of extracellular stimuli such as inflammatory cytokines, heat shock and ischemia.
L-JNKi1 (CAS 1445179-97-4 D-isomer) References
- p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1). | Varela-Rey, M., et al. 2002. FEBS Lett. 528: 133-8. PMID: 12297293
- Experimental and interventional dietary study in humans on the role of HDL fatty acid composition in PGI2 release and Cox-2 expression by VSMC. | Escudero, I., et al. 2003. Eur J Clin Invest. 33: 779-86. PMID: 12925037
- Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. | Falluel-Morel, A., et al. 2004. J Neurochem. 91: 1231-43. PMID: 15569266
- JNK1 activation mediates C5b-9-induced P0 mRNA instability and P0 gene expression in Schwann cells. | David, S., et al. 2006. J Peripher Nerv Syst. 11: 77-87. PMID: 16519786
- Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R. | Sydlik, U., et al. 2006. Am J Physiol Lung Cell Mol Physiol. 291: L725-33. PMID: 16751223
- c-Jun N-terminal kinase mediates constitutive human eosinophil apoptosis. | Hasala, H., et al. 2007. Pulm Pharmacol Ther. 20: 580-7. PMID: 16934508
- Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase. | Granziera, C., et al. 2007. Brain Res. 1148: 217-25. PMID: 17362885
- First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis. | Hasala, H., et al. 2007. Allergy Asthma Proc. 28: 79-86. PMID: 17390763
- D-JNKi, a peptide inhibitor of c-Jun N-terminal kinase, promotes functional recovery after transient focal cerebral ischemia in rats. | Esneault, E., et al. 2008. Neuroscience. 152: 308-20. PMID: 18262367
- Role of JNK in network formation of human lung microvascular endothelial cells. | Medhora, M., et al. 2008. Am J Physiol Lung Cell Mol Physiol. 294: L676-85. PMID: 18263671
- The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane. | Cantore, M., et al. 2011. J Biol Chem. 286: 45014-29. PMID: 22057277
- 25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells. | Koarai, A., et al. 2012. Respir Res. 13: 63. PMID: 22849850
- Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release. | Nisticò, R., et al. 2015. Sci Rep. 5: 9035. PMID: 25762148
Inhibitor of:
JNK1, JNK2, JNK3, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-JNKi1, 1 mg | sc-300882 | 1 mg | $319.00 |