Molecular structure of JNK Inhibitor VIII, CAS Number: 894804-07-0
JNK Inhibitor VIII (CAS 894804-07-0)
See product citations (2)
Alternate Names:
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
Application:
JNK Inhibitor VIII is an inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release
CAS Number:
894804-07-0
Purity:
≥95%
Molecular Weight:
356.37
Molecular Formula:
C18H20N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JNK inhibitor VIII is an inhibitor of c-Jun N-terminal kinases (JNK) that has been reported to suppress apoptosis, caspase cleavage, and cytochrome C release. Studies indicate that the inhibitor can block the phosphorylation of JNK without affecting the expression of IL-6, IL-8, or COX-2. JNK activity studies demonstrate that JNK Inhibitor VIII inhibits the phosphorylation of JNKAR1 and response to anisomycin (sc-3524). Additionally, JNK Inhibitor VIII has been noted to reduce TGF-induced JNK activation. It is also an inhibitor of JNK1, JNK2 and JNK3.
JNK Inhibitor VIII (CAS 894804-07-0) References
- Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. | Szczepankiewicz, BG., et al. 2006. J Med Chem. 49: 3563-80. PMID: 16759099
- Activation of c-Jun N-terminal kinase is essential for oxidative stress-induced Jurkat cell apoptosis by monochloramine. | Ogino, T., et al. 2009. Leuk Res. 33: 151-8. PMID: 18718660
- Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. | Kluwe, J., et al. 2010. Gastroenterology. 138: 347-59. PMID: 19782079
- Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells. | Turpeinen, T., et al. 2010. J Pharmacol Exp Ther. 333: 310-8. PMID: 20089808
- Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. | Fosbrink, M., et al. 2010. Proc Natl Acad Sci U S A. 107: 5459-64. PMID: 20212108
- A vaccinia virus-driven interplay between the MKK4/7-JNK1/2 pathway and cytoskeleton reorganization. | Pereira, AC., et al. 2012. J Virol. 86: 172-84. PMID: 22031940
- The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1. | Korhonen, R., et al. 2012. Mol Immunol. 51: 219-26. PMID: 22464096
- Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. | Ngoei, KR., et al. 2013. Biochim Biophys Acta. 1834: 1077-88. PMID: 23410953
- A novel retro-inverso peptide is a preferential JNK substrate-competitive inhibitor. | Ngoei, KR., et al. 2013. Int J Biochem Cell Biol. 45: 1939-50. PMID: 23792175
- MEK/ERK activation plays a decisive role in yellow fever virus replication: implication as an antiviral therapeutic target. | Albarnaz, JD., et al. 2014. Antiviral Res. 111: 82-92. PMID: 25241249
- The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons. | Guha, I., et al. 2016. Neurobiol Aging. 46: 138-48. PMID: 27490965
- FOSB⁻PCDHB13 Axis Disrupts the Microtubule Network in Non-Small Cell Lung Cancer. | Ting, CH., et al. 2019. Cancers (Basel). 11: PMID: 30658436
- The small molecule AZD6244 inhibits dengue virus replication in vitro and protects against lethal challenge in a mouse model. | de Oliveira, LC., et al. 2020. Arch Virol. 165: 671-681. PMID: 31942645
- Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesized insulin receptors to the cell surface. | Brown, M., et al. 2020. Mol Biol Cell. 31: 2597-2629. PMID: 32877278
Inhibitor of:
4933407C03Rik, Apoptosis, Bhlhb9, C130060K24Rik, C130074G19Rik, C130079G13Rik, C230072F16Rik, C230096C10Rik, CKAP4, DcR2, EF-HC2, EG382265, EG432798, FBXW22, GIPC, Gm4788, IRS-4, JNK1, JNK2, JNK3, LOC643260, LRRC37B, Olfr518, Olfr519, Olfr52, Olfr530, Olfr531, Olfr532, Olfr533, Olfr535, Olfr594, Olfr653, Olfr804, Olfr922, OTTMUSG00000011097, OTTMUSG00000016327, PKDCC, PRAMEF8, Ser/Thr Protein Kinase, TMEM232, and TTP.Activator of:
BC052486, Bob 1, brachyury, C1sb, CARD 11, CARD 9, CD69, CRIK, E130203B14Rik, EDARADD, EG381582, EG382639, EG625424, EG625464, FGF-15, fzr, GOLGA6L, GPNMB, Id4, IL-17, LHX2, Rad17, and SUSD3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNK Inhibitor VIII, 5 mg | sc-202673 | 5 mg | $267.00 |