JNK inhibitor VIII is an inhibitor of c-Jun N-terminal kinases (JNK) that has been reported to suppress apoptosis, caspase cleavage, and cytochrome C release. Studies indicate that the inhibitor can block the phosphorylation of JNK without affecting the expression of IL-6, IL-8, or COX-2. JNK activity studies demonstrate that JNK Inhibitor VIII inhibits the phosphorylation of JNKAR1 and response to anisomycin (sc-3524). Additionally, JNK Inhibitor VIII has been noted to reduce TGF-induced JNK activation. JNK Inhibitor VIII is an inhibitor of JNK1, JNK2 and JNK3.
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