Molecular structure of p38 MAP Kinase Inhibitor IV, CAS Number: 1638-41-1
p38 MAP Kinase Inhibitor IV (CAS 1638-41-1)
Alternate Names:
MT4; 2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol)
Application:
p38 MAP Kinase Inhibitor IV is an ATP-competitive p38α/β MAPK inhibitor
CAS Number:
1638-41-1
Purity:
≥95%
Molecular Weight:
456.94
Molecular Formula:
C12H4Cl6O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
p38 MAP Kinase Inhibitor IV is a cell permeable sulfone compound which functions as an ATP-competitive inhibitor of p38α and p38β MAP Kinases. In addition, p38 MAP Kinase Inhibitor IV inhibits p38γ/δ, ERK1/2, and JNK1/2/3 to a lesser extent. Furthermore, studies indicate that p38 MAP Kinase Inhibitor IV suppresses LPS-induced IL-1β release from hPBMC more effectively than SB 203850. Since MAP Kinases are responsible for signal transduction in cascade controlling cellular responses the inhibitor can possibly be used to inhibit apoptosis and other responses to stress stimuli.
p38 MAP Kinase Inhibitor IV (CAS 1638-41-1) References
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- Pro-inflammatory angiogenesis is mediated by p38 MAP kinase. | Rajashekhar, G., et al. 2011. J Cell Physiol. 226: 800-8. PMID: 20803566
- HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs. | He, X., et al. 2017. Oncotarget. 8: 1247-1261. PMID: 27901487
- The Host Cell Transcription Factor EGR1 Is Induced by Bacteria through the EGFR-ERK1/2 Pathway. | de Klerk, N., et al. 2017. Front Cell Infect Microbiol. 7: 16. PMID: 28180113
- Protective effect of CDDO-ethyl amide against high-glucose-induced oxidative injury via the Nrf2/HO-1 pathway. | Zhang, CX., et al. 2017. Spine J. 17: 1017-1025. PMID: 28343048
- Impact of omega-3 fatty acids on expression of angiogenic cytokines and angiogenesis by adipose-derived stem cells. | Parshyna, I., et al. 2017. Atheroscler Suppl. 30: 303-310. PMID: 29096855
- The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75. | Zhang, DW., et al. 2020. J Enzyme Inhib Med Chem. 35: 906-912. PMID: 32228103
- The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer. | Wang, K., et al. 2020. Nat Commun. 11: 2689. PMID: 32483206
- Cell Death and Transcriptional Responses Induced in Larvae of the Nematode Haemonchus contortus by Toxins/Toxicants with Broad Phylogenetic Efficacy. | Jasmer, DP., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34206464
- Transcriptional and Post-Translational Regulation of Junctional Adhesion Molecule-B (JAM-B) in Leukocytes under Inflammatory Stimuli. | Day-Walsh, PE., et al. 2022. Int J Mol Sci. 23: PMID: 35955781
Inhibitor of:
Apoptosis, ERK 1, ERK 2, JNK1, JNK2, JNK3, p38 alpha, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p38 MAP Kinase Inhibitor IV, 5 mg | sc-204159 | 5 mg | $260.00 |