p38 MAP Kinase Inhibitor IV CAS: 1638-41-1
MF: C12H4Cl6O4S
MW: 456.94
An ATP-competitive p38α/β MAPK inhibitor.

p38 MAP Kinase Inhibitor IV (CAS 1638-41-1)

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Synonym: MT4; 2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol)
Application: An ATP-competitive p38α/β MAPK inhibitor
CAS Number: 1638-41-1
Purity: ≥95%
Molecular Weight: 456.94
Molecular Formula: C12H4Cl6O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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p38 MAP Kinase Inhibitor IV is a cell permeable sulfone compound which functions as an ATP-competitive inhibitor of p38α and p38β MAP Kinases. In addition, p38 MAP Kinase Inhibitor IV inhibits p38&gamma/δ, ERK1/2, and JNK1/2/3 to a lesser extent. Furthermore, studies indicate that p38 MAP Kinase Inhibitor IV suppresses LPS-induced IL-1&beta release from hPBMC more effectively than SB 203850. Since MAP Kinases are responsible for signal transduction in cascade controlling cellular responses the inhibitor can possibly be used to inhibit apoptosis and other responses to stress stimuli.


1. Pargellis, C., et al. 2002. Nat. Struct. Biol. 9: 268-272. PMID: 11896401
2. Rajashekhar, G., et al. 2011. J. Cell. Physiol. 226: 800-808. PMID: 20803566

Physical State :
Solubility :
Soluble in DMSO.
Storage :
Store at 4° C
Melting Point :
228.80° C (Predicted)
Boiling Point :
590.05° C at 760 mmHg (Predicted)
Density :
1.86 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
p38α MAPK: IC50 = 130 nM; p38β MAPK: IC50 = 550 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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Certificate of Analysis

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