Molecular structure of JNK Inhibitor V, CAS Number: 345987-15-7
JNK Inhibitor V (CAS 345987-15-7)
See product citations (3)
Alternate Names:
1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile
Application:
JNK Inhibitor V is a JNK1, JNK2, and JNK3 inhibitor
CAS Number:
345987-15-7
Purity:
>95%
Molecular Weight:
372.45
Molecular Formula:
C20H16N6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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JNK Inhibitor V is a potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC50 = 150nM, hJNK2: IC50 = 220nM and hJNK3: IC50 = 70 nM). Experiments have reported JNK signaling pathway to play a role in ischemia-induced cell death in hippocampal CA1 neurons in a gerbil model. Therefore, preventing the activation of JNK has the potential of being neuroprotective. Additionally, in murine studies, the compound has been observed to reduce infarct size caused by myocardial ischemia. JNK Inhibitor V has also been noted to display anti-inflammatory capacities.
JNK Inhibitor V (CAS 345987-15-7) References
- AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. | Carboni, S., et al. 2004. J Pharmacol Exp Ther. 310: 25-32. PMID: 14988419
- Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats. | Ferrandi, C., et al. 2004. Br J Pharmacol. 142: 953-60. PMID: 15210584
- Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. | Gaillard, P., et al. 2005. J Med Chem. 48: 4596-607. PMID: 15999997
- C-Jun N-terminal kinase regulates adenosine A1 receptor-mediated synaptic depression in the rat hippocampus. | Brust, TB., et al. 2007. Neuropharmacology. 53: 906-17. PMID: 17967469
- The contribution of c-Jun N-terminal kinase activation and subsequent Bcl-2 phosphorylation to apoptosis induction in human B-cells is dependent on the mode of action of specific stresses. | Muscarella, DE. and Bloom, SE. 2008. Toxicol Appl Pharmacol. 228: 93-104. PMID: 18201741
- The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages. | Lunov, O., et al. 2010. Biomaterials. 31: 5063-71. PMID: 20381862
- The trophic effect of ouabain on retinal ganglion cell is mediated by EGF receptor and PKC delta activation. | Corrêa, Gde R., et al. 2010. Neurochem Res. 35: 1343-52. PMID: 20499167
- Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes. | Lunov, O., et al. 2010. Biomaterials. 31: 9015-22. PMID: 20739059
- IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin up-regulation. | Roca, H., et al. 2012. J Cell Biochem. 113: 1569-80. PMID: 22174091
- AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells. | Cerbone, A., et al. 2012. PPAR Res. 2012: 269751. PMID: 22619672
- TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner. | Badmann, A., et al. 2012. Cell Death Dis. 3: e447. PMID: 23254290
- The MAPK pathway signals telomerase modulation in response to isothiocyanate-induced DNA damage of human liver cancer cells. | Lamy, E., et al. 2013. PLoS One. 8: e53240. PMID: 23382840
- Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. | Garcia, DG., et al. 2015. Mol Cancer. 14: 105. PMID: 25976744
- Activation of PERK Contributes to Apoptosis and G2/M Arrest by Microtubule Disruptors in Human Colorectal Carcinoma Cells ‡. | Wu, MS., et al. 2019. Cancers (Basel). 12: PMID: 31906029
Inhibitor of:
C030039L03Rik, C030046E11Rik, CKR-7, DUSP22, IL-28B, JIP-2, JNK1, JNK2, JNK3, MAP-9, MPK-1, Pelle, Ref-1, RHOBTB3, Ser/Thr Protein Kinase, SPEER-3, T-bet, and ZAP-70.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JNK Inhibitor V, 1 mg | sc-202672A | 1 mg | $60.00 | |||
JNK Inhibitor V, 5 mg | sc-202672 | 5 mg | $169.00 |