SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ATF-2 (Thr 71) | sc-24532 | 0.5 mg/0.1 ml | $96.00 | |||
ATF-2 (Thr 71) acts as a modulator of JNK1 activity, influencing downstream signaling cascades through its phosphorylation state. This compound uniquely interacts with the enzyme's regulatory domains, stabilizing inactive conformations and thereby inhibiting substrate access. Its kinetic profile reveals a non-competitive inhibition mechanism, which suggests a nuanced role in cellular stress responses. The distinct molecular interactions highlight its potential to fine-tune JNK1-mediated pathways. | ||||||
c-Jun (Ser 63/73) | sc-24536 | 0.5 mg/0.1 ml | $96.00 | 3 | ||
c-Jun (Ser 63/73) serves as a pivotal transcription factor within the JNK1 signaling pathway, undergoing phosphorylation that enhances its transcriptional activity. This modification promotes its binding affinity to specific DNA sequences, facilitating the recruitment of co-activators and chromatin remodeling complexes. The kinetics of c-Jun activation are tightly regulated, allowing for rapid responses to cellular stress, while its interactions with other proteins can modulate the transcriptional output, underscoring its role in gene expression regulation. | ||||||