Date published: 2026-1-10

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JNK1 Substrates

Santa Cruz Biotechnology now offers a broad range of JNK1 Substrates for use in various applications. JNK1 substrates are essential molecules in the study of c-Jun N-terminal kinases (JNKs), which are crucial components of cellular signaling pathways. These substrates are phosphorylated by JNK1, an enzyme that plays a vital role in regulating various cellular processes, including stress response, apoptosis, and differentiation. By providing specific substrates, researchers can explore the activity and regulation of JNK1 in different biological contexts, enabling a deeper understanding of signal transduction mechanisms. The availability of these substrates facilitates experiments designed to study the molecular pathways influenced by JNK1, contributing to advancements in fields such as molecular biology, biochemistry, and cellular biology. Moreover, JNK1 substrates are invaluable in the development of assays and high-throughput screening techniques that aim to identify new modulators of JNK1 activity, further expanding our knowledge of this enzyme's role in complex biological systems. The comprehensive range of JNK1 substrates offered by Santa Cruz Biotechnology supports cutting-edge research and innovation, providing scientists with the tools needed to drive forward their investigations into cellular signaling and function. View detailed information on our available JNK1 Substrates by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

ATF-2 (Thr 71)

sc-24532
0.5 mg/0.1 ml
$96.00
(0)

ATF-2 (Thr 71) acts as a modulator of JNK1 activity, influencing downstream signaling cascades through its phosphorylation state. This compound uniquely interacts with the enzyme's regulatory domains, stabilizing inactive conformations and thereby inhibiting substrate access. Its kinetic profile reveals a non-competitive inhibition mechanism, which suggests a nuanced role in cellular stress responses. The distinct molecular interactions highlight its potential to fine-tune JNK1-mediated pathways.

c-Jun (Ser 63/73)

sc-24536
0.5 mg/0.1 ml
$96.00
3
(0)

c-Jun (Ser 63/73) serves as a pivotal transcription factor within the JNK1 signaling pathway, undergoing phosphorylation that enhances its transcriptional activity. This modification promotes its binding affinity to specific DNA sequences, facilitating the recruitment of co-activators and chromatin remodeling complexes. The kinetics of c-Jun activation are tightly regulated, allowing for rapid responses to cellular stress, while its interactions with other proteins can modulate the transcriptional output, underscoring its role in gene expression regulation.