JMJD1C Activators
The chemical class of JMJD1C activators comprises a diverse range of compounds, primarily influencing gene expression and chromatin remodeling, thereby potentially modulating the activity of JMJD1C indirectly. These compounds function through various mechanisms, impacting cellular pathways that converge on epigenetic regulation, a key area of JMJD1C's function. The primary mechanism through which these compounds exert their effects is through the modulation of signaling pathways and transcription factors that govern gene expression and chromatin state.
Compounds such as resveratrol, metformin, and sulforaphane influence epigenetic regulation through the activation of proteins like SIRT1, AMPK, and Nrf2. These proteins are involved in processes such as histone deacetylation, energy metabolism, and oxidative stress response, which are critical for chromatin remodeling and gene expression. By influencing these pathways, these compounds can indirectly affect the activity of JMJD1C, a histone demethylase, by altering the chromatin landscape and gene expression profiles. Furthermore, compounds like curcumin, EGCG, and quercetin modulate gene expression and chromatin state through their effects on various cellular signaling pathways. These changes in gene expression and chromatin remodeling can lead to an adaptive response in JMJD1C activity. Additionally, micronutrients like vitamin D3, retinoic acid, and zinc play a role in regulating gene expression and chromatin state, thereby potentially influencing JMJD1C activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes, can activate SIRT1, a sirtuin involved in histone deacetylation. SIRT1 activation may influence chromatin remodeling and gene expression, indirectly affecting JMJD1C activity in the process of epigenetic regulation. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMPK, a master regulator of cellular energy metabolism. AMPK activation can lead to alterations in gene expression and chromatin state, potentially influencing JMJD1C activity indirectly. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2, a transcription factor involved in cellular defense against oxidative stress. This activation can lead to changes in gene expression and potentially influence JMJD1C activity indirectly through alterations in the chromatin state. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects multiple signaling pathways and can influence gene expression and chromatin remodeling. This may lead to an indirect influence on JMJD1C activity through its role in epigenetic regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP may modulate gene expression and chromatin remodeling, potentially influencing JMJD1C activity indirectly. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a catechin in green tea, influences gene expression and chromatin remodeling. It may indirectly influence JMJD1C activity through its role in epigenetic regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, affects various signaling pathways and could indirectly influence JMJD1C activity through its role in gene expression and chromatin remodeling. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-Lipoic Acid affects cellular metabolism and may indirectly influence JMJD1C activity through changes in gene expression and chromatin state. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Niacin influences cellular metabolism and can indirectly affect JMJD1C through its role in gene expression and chromatin remodeling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, a metabolite of vitamin A, influences gene expression and chromatin remodeling, potentially affecting JMJD1C activity indirectly through its role in epigenetic regulation. | ||||||