JAM-C Activators
AM-C activators encompass a diverse range of chemicals, primarily focused on modulating cell adhesion, inflammation, and signaling pathways related to these processes. These activators do not bind directly to JAM-C but influence its function by altering the cellular environment or the activity of pathways that control cell adhesion and migration. The mechanisms by which these chemicals exert their effects are varied, ranging from the modulation of cAMP levels (as seen with Forskolin) to the regulation of inflammatory responses (e.g., Resveratrol, Curcumin).
The effectiveness of these activators in influencing JAM-C function can be dependent on the specific cellular context, as JAM-C is involved in multiple processes like endothelial cell permeability, leukocyte transmigration, and cancer metastasis. These activators typically work by either enhancing the signaling pathways that upregulate JAM-C expression or by modifying the cellular environment to make it conducive for JAM-C-mediated adhesion. For example, PMA's activation of protein kinase C can lead to a cascade of events affecting JAM-C, while EGCG's modulation of inflammation can alter the cellular context in which JAM-C operates.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpene that increases intracellular cAMP levels, potentially influencing signaling pathways that indirectly activate JAM-C. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major green tea component, modulates cell adhesion and inflammation-related pathways, potentially affecting JAM-C activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol in grapes, Resveratrol exhibits anti-inflammatory properties and modulates cell signaling, possibly influencing JAM-C function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, from turmeric, affects multiple signaling pathways and could indirectly modulate JAM-C. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
As a nitric oxide donor, it can modulate cell signaling and inflammation, impacting JAM-C-mediated cell adhesion. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), influencing cellular pathways that could affect JAM-C function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences the Wnt/β-catenin signaling pathway, affecting cell adhesion molecules, including potentially JAM-C. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, it modulates inflammation and oxidative stress, potentially influencing JAM-C. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Regulates various cellular functions and could indirectly affect JAM-C function through immune modulation and cell signaling. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Activates TGF-β signaling, modulating cell adhesion and migration, potentially influencing JAM-C function. | ||||||