Jagged Activators
Jagged1 Activators are an array of chemical compounds that indirectly enhance the functional activity of Jagged1 through a variety of signaling pathways. For instance, the gamma-secretase inhibitor DAPT prevents the cleavage of Notch receptors, leading to an increased presence of membrane-bound Jagged1, which in turn facilitates more effective Notch pathway activation. Similarly, the Smoothened Agonist (SAG) indirectly bolsters Jagged1 activity by activating the Hedgehog signaling pathway, which may enhance the crosstalk with Notch signaling. Ionomycin, by elevating intracellular calcium, and PMA through PKC activation, both contribute to the potential increase in Notch activation by Jagged1. Lithium chloride and BIO, both GSK-3 inhibitors, stabilize beta-catenin, a molecule that can enhance the interaction between Jagged1 and Notch. Bay K8644, by acting as an L-type calcium channel agonist, and Forskolin, by raising cAMP levels, both can modulate intracellular signaling in a manner that might augment Jagged1-mediated Notch activation.
Additionally, Anagrelide, which enhances cAMP levels through PDE III inhibition, and Curcumin, known to suppress NF-kB signaling, could further influence the Notch signaling dynamics, potentially facilitating Jagged1's role in Notch receptor activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Gamma-secretase inhibitor DAPT blocks the cleavage of Notch receptors, thus increasing the availability of membrane-bound Jagged1 for interaction with Notch on adjacent cells, facilitating Notch pathway activation. | ||||||
SAG | 912545-86-9 | sc-212905 sc-212905A | 1 mg 5 mg | $166.00 $421.00 | 27 | |
SAG activates the Hedgehog signaling pathway, which can crosstalk with the Notch pathway where Jagged1 is a ligand, potentially enhancing Jagged1-mediated Notch signaling in adjacent cells. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, which can promote the cleavage and activation of Notch receptors, thereby potentially enhancing the activation of Notch by Jagged1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate Notch receptor, increasing its activity and potentially enhancing the interaction with its ligand Jagged1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), leading to stabilization of beta-catenin, a component that can modulate Notch signaling, potentially increasing Jagged1-mediated activation of Notch. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
BIO is a GSK-3 inhibitor that stabilizes beta-catenin, which can interact with components of the Notch signaling pathway, possibly enhancing the functional activity of Jagged1. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K8644 is an L-type calcium channel agonist that increases intracellular calcium, potentially enhancing Notch receptor cleavage and activation, thereby augmenting Jagged1's role in Notch signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates cAMP levels, which can modulate various signaling pathways, including the Notch pathway, potentially leading to enhanced activation of Notch receptors by Jagged1. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $150.00 | ||
Anagrelide inhibits phosphodiesterase III, leading to increased cAMP levels that can influence Notch signaling, possibly enhancing the interaction and activation of Notch receptors by Jagged1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-kB signaling, which might result in altered Notch signaling dynamics, potentially increasing the activity of Jagged1 in activating Notch receptors. | ||||||