GSK-3 Inhibitor IX (BIO) is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α and GSK-3β (IC50 = 5 nM). GSK-3 (Glycogen synthase kinase-3) plays important roles in numerous signaling pathways that regulate a variety of cellular processes including cell proliferation, differentiation, apoptosis and embryonic development. GSK-3 Inhibitor IX also inhibits PKB Kinase (phosphoinositide-dependent kinase 1; PDK1 or PDPK1), a master kinase responsible for the activation of AKT/PKB, PKC, p70 S6 kinase (S6K) and SGK (serum/glucocorticoid regulated kinase). Research shows that PKB Kinase inhibition halts endothelial cell migration. GSK-3 Inhibitor IX has been been widely-used in embryonic stem cell studies to maintain human embryonic stem cells in their undifferentiated state, and to sustain expression of the pluripotent state-specific transcription factors Oct-3/4, Rex-1 and Nanog. GSK-3 Inhibitor IX has been shown to induce the differentiation of neonatal cardiomyocytes and maintain self-renewal in both human and mouse embryonic stem cells through wnt signaling activation.
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See how others have used GSK-3 Inhibitor IX (CAS 667463-62-9). Click on the entry to view the PubMed entry .
PMID: # 30388586 2019. Spectrochim Acta A Mol Biomol Spectrosc. 209: 150-164.
PMID: # 30984989 2019. Turk Neurosurg. 29: 513-521.
PMID: # 30412805 2019. J Pharm Biomed Anal. 164: 317-325.
PMID: # 26831110 Iovino, S.|Burkart, AM.|Warren, L.|Patti, ME.|Kahn, CR.| et al. 2016. Proc. Natl. Acad. Sci. U.S.A. 113: 1889-94.
PMID: # 27997540 Li, Y. et al. 2016. PLoS Med. 13: e1002200.
PMID: # 22574208 Shao, M. et al. 2012. PLoS ONE. 7: e36655.
PMID: # 32430065 Biol. Res. 53: 22.
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