Molecular structure of GSK-3 Inhibitor IX, CAS Number: 667463-62-9
GSK-3 Inhibitor IX (CAS 667463-62-9)
See product citations (10)
Alternate Names:
GSK-3 Inhibitor IX is also known as BIO.
Application:
GSK-3 Inhibitor IX is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α and GSK-3β.
CAS Number:
667463-62-9
Purity:
>97%
Molecular Weight:
356.17
Molecular Formula:
C16H10BrN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GSK-3 Inhibitor IX (BIO) is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α and GSK-3β (IC50 = 5 nM). GSK-3 (Glycogen synthase kinase-3) plays important roles in numerous signaling pathways that regulate a variety of cellular processes including cell proliferation, differentiation, apoptosis and embryonic development. GSK-3 Inhibitor IX also inhibits PKB Kinase (phosphoinositide-dependent kinase 1 PDK1 or PDPK1), a master kinase responsible for the activation of AKT/PKB, PKC, p70 S6 kinase (S6K) and SGK (serum/glucocorticoid regulated kinase). Research shows that PKB Kinase inhibition halts endothelial cell migration. GSK-3 Inhibitor IX has been been widely-used in embryonic stem cell studies to maintain human embryonic stem cells in their undifferentiated state, and to sustain expression of the pluripotent state-specific transcription factors Oct-3/4, Rex-1 and Nanog. GSK-3 Inhibitor IX may act to induce the differentiation of neonatal cardiomyocytes and maintain self-renewal in both human and mouse embryonic stem cells through wnt signaling activation.
GSK-3 Inhibitor IX (CAS 667463-62-9) References
- GSK-3-selective inhibitors derived from Tyrian purple indirubins. | Meijer, L., et al. 2003. Chem Biol. 10: 1255-66. PMID: 14700633
- Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. | Polychronopoulos, P., et al. 2004. J Med Chem. 47: 935-46. PMID: 14761195
- The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. | Tseng, AS., et al. 2006. Chem Biol. 13: 957-63. PMID: 16984885
- Inverse in silico screening for identification of kinase inhibitor targets. | Zahler, S., et al. 2007. Chem Biol. 14: 1207-14. PMID: 18022559
- Regulation of protein stability by GSK3 mediated phosphorylation. | Xu, C., et al. 2009. Cell Cycle. 8: 4032-9. PMID: 19923896
- Signal transduction to the permeability transition pore. | Rasola, A., et al. 2010. FEBS Lett. 584: 1989-96. PMID: 20153328
- Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. | Spokoini, R., et al. 2010. Mol Endocrinol. 24: 1136-50. PMID: 20371704
- Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. | Ibrahim, SH., et al. 2011. J Hepatol. 54: 765-72. PMID: 21147505
- GSK-3 activity is critical for the orientation of the cortical microtubules and the dorsoventral axis determination in zebrafish embryos. | Shao, M., et al. 2012. PLoS One. 7: e36655. PMID: 22574208
- Polycyclic aromatic hydrocarbons and dibutyl phthalate disrupt dorsal-ventral axis determination via the Wnt/β-catenin signaling pathway in zebrafish embryos. | Fairbairn, EA., et al. 2012. Aquat Toxicol. 124-125: 188-96. PMID: 22975441
- Characterization and function of a β-catenin homolog from Litopenaeus vannamei in WSSV infection. | Sun, J., et al. 2017. Dev Comp Immunol. 76: 412-419. PMID: 28689772
- Glycogen synthase kinase-3 inhibition in glioblastoma multiforme cells induces apoptosis, cell cycle arrest and changing biomolecular structure. | Acikgoz, E., et al. 2019. Spectrochim Acta A Mol Biomol Spectrosc. 209: 150-164. PMID: 30388586
- Effects of Glycogen Synthase Kinase Inhibitor on Glioblastoma Multiforme Cell Line via Apoptosis and Cell Signaling Pathways. | Camlar, M., et al. 2019. Turk Neurosurg. 29: 513-521. PMID: 30984989
- GSK3beta inhibitor-induced dental mesenchymal stem cells regulate ameloblast differentiation. | Yamada, A., et al. 2022. J Oral Biosci. 64: 400-409. PMID: 36270608
Inhibitor of:
BC052486, BC052688, BC053393, BC061212, BTG2, CCDC150, CDH20, Cdk5, claudin 13, Dapper3, DBX2, DNAHC12, ER81, ESC, FAM48B2, Fbxw21, FOXL1, GATA-5, GBE1, GCK, GCP5, Gm15070, GSK-3 alpha, GSKIP, HESX1, IDAS, Intelectin-b, IRX5, LGR6, LHX3, LMO6, Nkx-2.5, Nkx-6.3, Nlk, NSUN3, NYAP2, Oct-3A, Olfr713, Olfr715, Olfr835, Olfr836, Olfr837, Olfr900, OTTMUSG00000005931, p35, PCDHAC1_Pcdhac1, PKB Kinase, POPX1, PPDPF, PYGM, Rad21, Sec61α2, Ser/Thr Protein Kinase, SPRN, Stim1, TBX20, TBX5, TFEB, TMEM170B, TRF2, UNCX, Wnt-3, X11γ, YAF2, YAP, ZNF200, and ZNRF1.Activator of:
α T-catenin, β-catenin, γB-crystallin, γPAK, 14-3-3 σ, 4931431F19Rik, ADP ribosylation factor (ARF), AIDA, ANKRD25, ANKRD36–Ankrd36, AP1GBP1, Armadillo (β-catenin), ATF-5, Atg4D, atonal, ATP4A, BAF170, BAR-1, BC051019, BCA3, BMP-1, BMP-3, BMP-9, BMP2K, BUBR1, c-Erb-A β-1, C14orf108, C1orf114, C1orf80, C86695, cadherin-22, cadherin-26, CARP, casein kinase Iγ1, casein kinase Iγ3, Caspr5-2, CD3-δ, Cdc7, CHST5, CKAP4, CKR-7, Collapsin response mediator protein (CRMP), Conductin, CSMD1, CYB5D2, D230039L06Rik, Dab2, DAN, Dapper1, Dapper3, DCC, DEC2, Delta-4, Deltex-4, dishevelled, Distal-less, Diversin, DIXDC1, Dkk-2, Dkk-3, Dkk-4, Dvl-1, Dvl-3, Ect2, EG245190, EG625424, EG625464, EG626215, EMBP, EphB1, ER71, F-Spondin, FAM128B, FOXD4, FRAT2, frizzled-1, frizzled-2, frizzled-3, frizzled-5, frizzled-7, frizzled-8, FRP-3, FRP-4, girdin, GLTSCR1, glycogen synthase 1, glypican-6, Gm765, GPR177, GRIP1, Hairless, HDA2, Helios, HepaCAM, HES5, HMX3_Hmx3, HNF-3γ, hnRNP M, HP1BP3, HRT1_Hrt1, ICAT, IFT46, IINTS1, INTU, IRX3, Jagged, Kremen-1, Kremen-2, LBH, LCORL, LEF-1, Lefty-1, Lefty-A, Lefty-B, LGR4, LGR5, LIN-31, LIT-1, LOC348751, LOC440338, LOC643008, LOC644070, LOC727954, LRP4, LRP5, LRP6, LRRC4B, LRRC54, LYPD3, M-cadherin, MAGI-1, Manic Fringe, MARCO, MATE1, MEF-2C, MESP2, MINK1, Myelin P2, N-Myc, Nanog, nephrocystin, Neurotrypsin, NKD1, NKD2, Nkx-2.2, Nkx-6.2, NORRIN, NUDE1, OLFM3, Olfr569, Olfr57, Olfr570, oskar, p8, Paraxis, PARD6G, PCNXL2, Pellino 1, plexin-A4, PRAMEF2, Prickle1, Prickle4, Proteassemblin, PSPC1, PTP22, Pygopus 1, Pygopus 2, R-Spondin, RBM26, Reg Iβ, ROR1, RUNX2, RWDD4A, SAV1, SEL-10, SHISA3, Slit3, SMG9, SNT-2, Sox-12, Sox-17, Sox-7, SRRD, SSX2, SUSD2, Svs7, T2-cadherin, TAF9A, TBX6, TCF-1, TCF-4, TCTE1, tinman, TMEM147, TMEM170B, TNIK, Vangl1, VRK2, WDR5, Wingless, WISP-2, WISP-3, Wnt-1, Wnt-10a, Wnt-10b, Wnt-11, Wnt-14, Wnt-15, Wnt-16, Wnt-2b, Wnt-3a, Wnt-5a, Wnt-5b, Wnt-6, Wnt-7b, Wnt-8b, ZNF281, ZNF585B, and ZNF862.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-3 Inhibitor IX, 1 mg | sc-202634 | 1 mg | $58.00 | |||
GSK-3 Inhibitor IX, 10 mg | sc-202634A | 10 mg | $188.00 | |||
GSK-3 Inhibitor IX, 50 mg | sc-202634B | 50 mg | $884.00 |