Date published: 2025-11-21

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insulin R Activators

Insulin R Activators comprises a diverse range of molecular entities that are capable of enhancing the activity of the insulin receptor (Insulin R). This receptor is an essential component of the insulin signaling pathway, a complex cascade of events that is initiated when insulin binds to its receptor, which is present on the surface of various cells throughout the body. Activation of the insulin receptor sets off a series of phosphorylation events, leading to the activation of several downstream pathways that are centrally involved in critical physiological processes such as the regulation of glucose homeostasis and cell growth, among others.Insulin R Activators can operate through a variety of mechanisms to stimulate the activity of the insulin receptor. Some may interact directly with the receptor, triggering a conformational change that enhances its affinity for insulin or its kinase activity. Others may operate indirectly, for example, by modulating the expression of the insulin receptor gene, thereby increasing the number of receptors present on the cell surface and enhancing the cell's overall responsiveness to insulin. Still, others may act by inhibiting the activity of protein tyrosine phosphatases, which are enzymes that can deactivate the insulin receptor by removing phosphate groups from it. Despite the differences in their modes of action, all Insulin R Activators share the common characteristic of being able to enhance the activity of the insulin receptor and, consequently, the insulin signaling pathway.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

bpV(pic)

148556-27-8sc-221379
sc-221379A
5 mg
25 mg
$86.00
$327.00
11
(1)

bpV(pic) or bisperoxo(1,10-phenanthroline)oxovanadate(V) is a chemical compound classified as an organovanadium compound. As an activator of the insulin receptor (Insulin R), it operates by inhibiting protein tyrosine phosphatases, a class of enzymes that dephosphorylate tyrosine residues on proteins. This action can enhance the phosphorylation status of the insulin receptor, thereby increasing its activation state and subsequently potentiating the downstream signaling of the insulin pathway.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic acid can affect gene transcription, which may upregulate the expression of insulin receptor.

IRTK Activator

sc-221765
5 mg
$260.00
(0)

The IRTK Activator is a chemical compound that acts on the insulin receptor tyrosine kinase (IRTK). It enhances the activity of IRTK, thereby facilitating the phosphorylation process essential for insulin signal transduction. The compound is often used in research to better understand insulin signaling mechanisms.

IRTK Activator, Negative Control

6172-50-5sc-221766
5 mg
$340.00
(0)

IRTK Activator, Negative Control (CAS 6172-50-5) is a compound used in biochemical research as a negative control when studying insulin receptor tyrosine kinase (IRTK) activity. While it shares structural similarities with certain IRTK activators, it does not possess the ability to activate the insulin receptor (Insulin R). Its role in studies is to provide a baseline or control condition against which the effects of actual IRTK activators on the insulin receptor can be compared.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$70.00
$160.00
$290.00
2
(1)

Cholecalciferol is involved in the regulation of multiple genes, including the insulin receptor, via its active metabolite.

Demethylasterriquinone B1

78860-34-1sc-203025
5 mg
$500.00
2
(1)

Demethylasterriquinone B1 (CAS 78860-34-1) is a quinone compound known to stimulate tyrosine kinase activity. This action enhances the phosphorylation and activation of the insulin receptor (Insulin R), promoting the downstream insulin signaling pathway.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$153.00
$1224.00
$12239.00
82
(1)

Insulin, with CAS number 11061-68-0, is a peptide hormone that serves as an activator of the insulin receptor (insulin R). It plays a crucial role in regulating glucose homeostasis by binding to its receptor, triggering a cascade of intracellular events that facilitate glucose uptake and metabolism. This compound is often studied to understand the biochemical pathways related to glucose regulation.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin has been shown to affect multiple cellular processes and genes, potentially including upregulation of the insulin receptor.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol may stimulate SIRT1, a sirtuin that is thought to upregulate the expression of insulin receptor.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein, a phytoestrogen, can modulate the expression of numerous genes, potentially including the insulin receptor.