bpV(pic) CAS: 148556-27-8
MF: K2[VO(O2)2C6H4NO2]•2H2O
MW: 367.28
A potent protein PTP inhibitor.

bpV(pic) (CAS 148556-27-8)

bpV(pic) | CAS 148556-27-8 is rated 5.0 out of 5 by 1.
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Alternate Names: Dipotassium bisperoxo (picolinato) oxovanadate (V)
Application: bpV(pic) is a potent protein PTP inhibitor
CAS Number: 148556-27-8
Purity: ≥90%
Molecular Weight: 367.28
Molecular Formula: K2[VO(O2)2C6H4NO2]•2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium, that is thought to act as an insulin mimetic. This compound has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells, stimulate lipogenesis in adipocytes, and inhibit the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes. bpV(pic) is also an inhibitor of G6Pase and PTP, and an activator of insulin R.


References

1. Posner, B.I., et al. 1994. J. Biol. Chem. 269: 4596-4604. PMID: 8308031

Physical State :
Solid
Solubility :
Soluble in water (3 mg/ml), and DMSO.
Storage :
Store at 4° C
IC50 :
PTEN: IC50 = 31 nM; PTP- β: IC50 = 12.7 µM; PTP-1 βB: IC50 = 61 µM
Ki Data :
Glucose-6-phosphatase : Ki= 0.42 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760324
SMILES :
O=C1[O-][V+3]23([N]4=CC=CC=C41)([O-][O-]2)([O-][O-]3)=O.[K+].[K+].O.O

Download SDS (MSDS)

Certificate of Analysis

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bpV(pic) (CAS 148556-27-8)  Product Citations

See how others have used bpV(pic) (CAS 148556-27-8). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 26704941  Lauzier, A. et al. 2016. Am. J. Pathol. 186: 359-74.

PMID: # 26550415  Guan, Y. et al. 2015. Int J Clin Exp Med. 8: 14308-15.

PMID: # 24686133  Saglam, A. et al. 2014. Neuroreport. 25: 549-55.

PMID: # 24610700  Wyatt, LA. et al. 2014. J. Comp. Neurol. 522: 2741-55.

PMID: # 23902250  Ajeawung, NF. et al. 2013. Future Oncol. 9: 1215-29.

PMID: # 23934019  Lerer-Serfaty, G. et al. 2013. J. Assist. Reprod. Genet. 30: 1279-88.

PMID: # 22561198  Christie, KJ. et al. 2012. Mol. Cell. Neurosci. 50: 179-92.

PMID: # 22898050  Kim, SA. et al. 2012. Biochem. Biophys. Res. Commun. 425: 866-72.

PMID: # 31866820  Front Mol Neurosci. 12: 281.

PMID: # 29559312  Biochem. Pharmacol. 152: 60-70.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from bpV(pic) was found to inhibit the action bpV(pic) was found to inhibit the action of lambda protein phosphatase. This was demonstrated by IF showing nuclear localization and increase in signal of phosphorylated NFkB p50 in the treated HeLa cells. -SCBT QC
Date published: 2015-01-04
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