Molecular structure of IRTK Activator
IRTK Activator
Alternate Names:
2,5-Dihydroxy-3-(1-methylindol-3-yl)-6-phenyl-1,4-benzoquinone
Application:
IRTK Activator is a potent and selective activator of IRTK
Molecular Weight:
345.35
Molecular Formula:
C21H15NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A potent and highly selective activator of insulin receptor tyrosine kinase (IRTK; EC50 = 300 nM in CHO cells expressing human insulin receptor). It does not activate other closely related receptors such as epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGFIR), and platelet-derived growth factor receptor (PDGFR) at concentrations up to 30 µM.
IRTK Activator References
- Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators. | Qureshi, SA., et al. 2000. J Biol Chem. 275: 36590-5. PMID: 10967116
- Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor. | Liu, K., et al. 2000. J Med Chem. 43: 3487-94. PMID: 11000003
Activator of:
insulin R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRTK Activator, 5 mg | sc-221765 | 5 mg | $265.00 |