INPP5F Inhibitors
INPP5F inhibitors belong to a class of chemical compounds designed to target and inhibit the activity of Inositol Polyphosphate-5-Phosphatase F (INPP5F), also known as SKIP. INPP5F is an important phosphatase enzyme that plays a critical role in cellular signaling pathways by regulating the levels of inositol phospholipids. Inositol phospholipids are essential components of cell membranes and are involved in a wide range of cellular processes, including signal transduction, membrane trafficking, and cytoskeleton organization.
INPP5F specifically catalyzes the dephosphorylation of inositol polyphosphate lipids, such as phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) and inositol 1,4,5-trisphosphate (IP3), leading to the generation of inositol bisphosphate lipids and inositol. Inhibitors of INPP5F are developed to interact with this enzyme, potentially disrupting its phosphatase activity and affecting downstream cellular processes regulated by inositol phospholipids.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a broad-spectrum inhibitor of PI3K, which would potentially reduce PI(3,4,5)P3 levels, thus indirectly affecting the function and possibly the expression of INPP5F due to altered feedback mechanisms within the phosphoinositide signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent inhibitor of PI3K and may lead to decreased PI(3,4,5)P3 levels. The reduced demand for INPP5F's phosphatase activity could influence its expression through compensatory regulatory pathways. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin, a statin, inhibits HMG-CoA reductase, which could indirectly affect lipid signaling pathways and potentially lead to downregulation of lipid phosphatases such as INPP5F by disrupting lipid rafts and related signaling. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine specifically inhibits Akt, a downstream target of PI(3,4,5)P3, which could indirectly lead to altered feedback loops within phosphoinositide signaling and affect the expression of INPP5F. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that could modulate cellular stress responses, potentially altering signaling pathways that regulate the expression of enzymes like INPP5F. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in PI3K/Akt signaling. The inhibition of mTOR could have downstream effects on the expression of phosphoinositide-related enzymes, including INPP5F. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK signaling pathways. Inhibition of JNK signaling could lead to alterations in transcription factors that regulate INPP5F expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that might affect the phosphorylation states of proteins involved in INPP5F regulation, thereby potentially influencing its expression. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine is an Akt inhibitor, and by disrupting Akt signaling, it could indirectly impact the expression of INPP5F within the PI3K/Akt pathway. | ||||||
NF 449 | 389142-38-5 | sc-203159 | 10 mg | $308.00 | 5 | |
NF449 is a potent Gs alpha subunit-specific antagonist which can influence cyclic AMP levels and thus might indirectly affect cAMP-dependent pathways that regulate INPP5F expression. | ||||||