Date published: 2025-11-11

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Triciribine (CAS 35943-35-2)

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Alternate Names:
API-2; NSC 154020; Tricyclic Nucleoside; Akt/PKB Signaling Inhibitor-2
Application:
Triciribine is a tricyclic nucleoside that induces apoptosis and has antineoplastic and antiviral activity
CAS Number:
35943-35-2
Purity:
≥97%
Molecular Weight:
320.30
Molecular Formula:
C13H16N6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Akt kinase inhibition may act to induce apoptosis and cell growth in cancer cell research. Triciribine can selectively inhibit Akt1, Akt2, and Akt3 without inhibiting known upstream activators,PDK1 and PI 3-Kinase, of Akt. Studies show that Triciribine induces apoptosis and inhibits cell growth in cells that express atypical Akt1. Additionally, Triciribine has antineoplastic and antiviral activity at low micromolar and submicromolar concentrations, and has been demonstrated to inhibit incorporation of amino acids into proteins and purine nucleotide synthesis. In both in vivo and in vitro scientific research, Triciribine has been employed extensively. By binding to the ATP-binding pocket of Akt, Triciribine effectively blocks its activity as a potent and selective inhibitor. Importantly, Triciribine′s efficacy has been demonstrated in inhibiting the phosphorylation of Akt substrates, such as the pro-apoptotic proteins Bad and caspase-9.


Triciribine (CAS 35943-35-2) References

  1. Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation.  |  Porcari, AR., et al. 2000. J Med Chem. 43: 2438-48. PMID: 10882371
  2. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.  |  Yang, L., et al. 2004. Cancer Res. 64: 4394-9. PMID: 15231645
  3. The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.  |  Dieterle, A., et al. 2009. Int J Cancer. 125: 932-41. PMID: 19422047
  4. Inhibition of CCRF-CEM human leukemic lymphoblasts by triciribine (tricyclic nucleoside, TCN, NSC-154020). Accumulation of drug in cells and comparison of effects on viability, protein synthesis and purine synthesis.  |  Moore, EC., et al. 1989. Biochem Pharmacol. 38: 4037-44. PMID: 2480791
  5. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis.  |  Abdalla, M., et al. 2015. Br J Pharmacol. 172: 4173-88. PMID: 26033700
  6. Triciribine Phosphate Monohydrate, an AKT Inhibitor, Enhances Gemcitabine Activity in Pancreatic Cancer Cells.  |  Kim, R., et al. 2015. Anticancer Res. 35: 4599-604. PMID: 26254348
  7. An Expedient Total Synthesis of Triciribine.  |  Hu, C., et al. 2017. Molecules. 22: PMID: 28420174
  8. Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction.  |  Liu, Q., et al. 2017. Theranostics. 7: 4001-4012. PMID: 29109794
  9. Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA.  |  Bjune, K., et al. 2018. Sci Rep. 8: 16174. PMID: 30385871
  10. Triciribine Engages ZFP36L1 and HuR to Stabilize LDLR mRNA.  |  Sundvold, H. 2020. Molecules. 25: PMID: 33019656
  11. Akt-independent effects of triciribine on ACE2 expression in human lung epithelial cells: Potential benefits in restricting SARS-CoV2 infection.  |  Adil, MS., et al. 2021. J Cell Physiol. 236: 6597-6606. PMID: 33624300
  12. PI3K/AKT/mTOR and TLR4/MyD88/NF-κB Signaling Inhibitors Attenuate Pathological Mechanisms of Allergic Asthma.  |  Ma, B., et al. 2021. Inflammation. 44: 1895-1907. PMID: 33860870
  13. Development and validation of LC/MS/MS method for Triciribine and its monophosphate metabolite in plasma and RBC: Application to mice pharmacokinetic studies.  |  Narayanan, S., et al. 2021. J Chromatogr B Analyt Technol Biomed Life Sci. 1174: 122714. PMID: 33962189

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Triciribine, 1 mg

sc-200661
1 mg
$102.00

Triciribine, 5 mg

sc-200661A
5 mg
$138.00