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NF 449 is a selective Gsα-subunit G-protein antagonist which reduces the association rate of guanosine 5'-[γ-thio]triphosphate ([35S]GTP[γS]) binding to Gα s -s (Gs&alpha-s) and inhibits the stimulation of adenylyl cyclase activity in S49 cyc- membranes. In addition, NF 449 interferes with binding between the Adenosine A1-R (A1-adenosine receptor) and its cognate G proteins (Gi/Go). Alternate studies suggest that NF449 inhibits a wide array of P2 receptors such as P2X3, P2Y1, and P2Y2, while showing the highest selectivity towards P2X1. Furthermore, NF449 can disrupt the coupling of β-AR (β-adrenergic receptors).
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See how others have used NF 449. Click on the entry to view the PubMed entry .
PMID: # 30731136 Höllerhage, M. et al. 2019. Neuropharmacology. 149: 13-26.
PMID: # 28611772 Villagra-Blanco, R.|Silva, LMR.|Muñoz-Caro, T.|Yang, Z.|Li, J.|Gärtner, U.|Taubert, A.|Zhang, X.|Hermosilla, C.| et al. 2017. Front Immunol. 8: 606.
PMID: # 24641330 Chi, Y. et al. 2014. British journal of pharmacology. 171: 3448-62.
PMID: # 22276108 Rasmuson, A. et al. 2012. PloS one. 7: e29331.
PMID: # 23022524 Kumar, DP. et al. 2012. Biochemical and biophysical research communications. 427: 600-5.
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