INO80B Activators
INO80B Activators are a collection of chemical compounds that indirectly enhance the functional activity of INO80B by influencing the chromatin context in which it operates. Compounds such as Trichostatin A, SAHA (Vorinostat), Scriptaid, RGFP966, and Apicidin function as histone deacetylase inhibitors, leading to an increase in acetylated histones. This hyperacetylation results in a looser chromatin structure, which may facilitate the chromatin remodeling activities of INO80B, such as nucleosome repositioning. Similarly, 5-Azacytidine and Nicotinamide act through inhibition of DNA methylation and sirtuin-mediated deacetylation, respectively, contributing to a chromatin state that could be more amenable to remodeling by INO80B. Anacardic acid, as a HAT inhibitor, modifies histone acetylation patterns, which could also indirectly support INO80B's role in chromatin alteration.
Inthe context of membrane dynamics, Methyl-β-cyclodextrin, by extracting cholesterol, may affect the recruitment of INO80B to chromatin, thus potentially enhancing its activity. Bisphenol A interacts with estrogen receptors and may influence gene expression and chromatin accessibility, indirectly affecting INO80B's function. The selective inhibition of HDACs by MS-275 (Entinostat) and RGFP966 specifically targets histone acetylation, creating a favorable environment for INO80B's action. Furthermore, I-CBP112 disrupts the interaction between acetylated histones and the bromodomain of CREBBP/EP300, which could lead to chromatin states that enhance INO80B-mediated remodeling processes. Collectively, these INO80B Activators, through their targeted effects on chromatin structure and composition, promote conditions that are conducive to the enhancement of INO80B's intrinsic activity in chromatin remodeling without directly interacting with the protein or its immediate substrates.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that promotes acetylation of histones. INO80B, being part of chromatin remodeling complexes, is facilitated in its function when the chromatin structure is more relaxed due to hyperacetylation, enhancing its activity in altering nucleosome positioning. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that reduces DNA methylation. This demethylation can lead to a more open chromatin state, potentially enhancing the role of INO80B in chromatin remodeling. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide acts as a sirtuin inhibitor which indirectly affects chromatin structure through histone deacetylation. A more open chromatin state may enhance the functional activity of INO80B in nucleosome repositioning. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid inhibits histone acetyltransferases (HATs), leading to changes in histone acetylation patterns. These changes may indirectly facilitate INO80B's chromatin remodeling activities. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
Methyl-β-cyclodextrin extracts cholesterol from membranes, influencing membrane fluidity and potentially the recruitment of INO80B to chromatin via altered nuclear membrane dynamics. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A can bind to estrogen receptors, potentially altering gene expression and chromatin structure. This may indirectly enhance INO80B activity by modifying the substrate on which INO80B acts. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is a histone deacetylase inhibitor that promotes a more open chromatin configuration, potentially enhancing the chromatin remodeling activity of INO80B. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 is a selective histone deacetylase inhibitor, leading to hyperacetylated histones and potentially a more accessible chromatin structure for INO80B to act upon. | ||||||
I-CBP112 | 1640282-31-0 | sc-507494 | 25 mg | $400.00 | ||
I-CBP112 is an inhibitor of the CREBBP/EP300 bromodomain, affecting histone acetylation levels and potentially favoring the functional activity of INO80B in chromatin remodeling. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
Scriptaid is a histone deacetylase inhibitor that can lead to a more relaxed chromatin state, potentially enhancing the activity of INO80B in nucleosome repositioning. | ||||||