INO80B Antibody (E-3): sc-390009
- INO80B Antibody (E-3) is a mouse monoclonal IgG2b κ INO80B antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 109-147 within an internal region of INO80B of human origin
- INO80B Antibody (E-3) is recommended for detection of INO80B of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-INO80B Antibody (E-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for INO80B Antibody (E-3) for WB applications. These reagents are now offered in bundles with INO80B Antibody (E-3) (see ordering information below).
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INO80B Antibody (E-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects INO80B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-INO80B antibody (E-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. INO80B, also known as ZNHIT4, PAPA1, or HMGA1L4, is a crucial component of the INO80 chromatin remodeling complex and plays a significant role in regulating gene expression and cell cycle progression. INO80B is localized to the nucleolus, where INO80B is highly expressed in the testis and functions to induce growth arrest by halting the cell cycle at the G1 phase. This regulation is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation, which can lead to tumorigenesis. INO80B′s expression is tightly controlled at the transcriptional level, peaking during the G0 and G1 phases of the cell cycle, and INO80B interacts with PAP-1, a splicing factor, suggesting INO80B′s involvement in nucleolar complexes that regulate ribosome biogenesis and cell cycle events. INO80B′s ability to modulate these critical processes underscores INO80B′s importance in cellular function and potential implications in cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
INO80B Antibody (E-3) References:
- Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa. | Keen, TJ., et al. 2002. Eur J Hum Genet. 10: 245-9. PMID: 12032732
- PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor. | Maita, H., et al. 2004. Exp Cell Res. 300: 283-96. PMID: 15474994
- Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex. | Maita, H., et al. 2005. Exp Cell Res. 302: 61-8. PMID: 15541726
- A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase. | Kuroda, TS., et al. 2004. Gene. 340: 83-98. PMID: 15556297
- CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. | Maita, H., et al. 2005. Exp Cell Res. 303: 375-87. PMID: 15652350
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
INO80B Antibody (E-3) | sc-390009 | 200 µg/ml | $322.00 | |||
INO80B Antibody (E-3): m-IgG Fc BP-HRP Bundle | sc-526115 | 200 µg Ab; 10 µg BP | $361.00 | |||
INO80B Antibody (E-3): m-IgG2b BP-HRP Bundle | sc-549681 | 200 µg Ab; 10 µg BP | $361.00 | |||
INO80B Antibody (E-3) AC | sc-390009 AC | 500 µg/ml, 25% agarose | $424.00 | |||
INO80B Antibody (E-3) HRP | sc-390009 HRP | 200 µg/ml | $322.00 | |||
INO80B Antibody (E-3) FITC | sc-390009 FITC | 200 µg/ml | $336.00 | |||
INO80B Antibody (E-3) PE | sc-390009 PE | 200 µg/ml | $349.00 | |||
INO80B Antibody (E-3) Alexa Fluor® 488 | sc-390009 AF488 | 200 µg/ml | $364.00 | |||
INO80B Antibody (E-3) Alexa Fluor® 546 | sc-390009 AF546 | 200 µg/ml | $364.00 | |||
INO80B Antibody (E-3) Alexa Fluor® 594 | sc-390009 AF594 | 200 µg/ml | $364.00 | |||
INO80B Antibody (E-3) Alexa Fluor® 647 | sc-390009 AF647 | 200 µg/ml | $364.00 | |||
INO80B Antibody (E-3) Alexa Fluor® 680 | sc-390009 AF680 | 200 µg/ml | $364.00 | |||
INO80B Antibody (E-3) Alexa Fluor® 790 | sc-390009 AF790 | 200 µg/ml | $364.00 | |||
INO80B (E-3) Neutralizing Peptide | sc-390009 P | 100 µg/0.5 ml | $69.00 |