IL-6Rα Inhibitors
Interleukin-6 receptor alpha (IL-6Rα) is a membrane-bound protein that plays a central role in mediating the cellular effects of interleukin-6 (IL-6), a pleiotropic cytokine involved in various physiological processes including inflammation, immune response, and hematopoiesis. IL-6 binds to IL-6Rα, forming a complex that subsequently associates with another membrane protein called gp130. This assembly initiates a cascade of intracellular signaling pathways, predominantly the JAK/STAT pathway, which culminates in the modulation of gene expression patterns in the cell. Given the wide range of biological processes influenced by IL-6, the precise regulation of IL-6Rα-mediated signaling is paramount. Dysregulation of this system can contribute to various pathophysiological conditions, underscoring the importance of understanding and modulating IL-6Rα activity.
IL-6Rα inhibitors are a class of chemical compounds designed to specifically target and modulate the activity of the IL-6Rα. These inhibitors function by preventing the binding of IL-6 to its receptor, thereby disrupting the subsequent signaling cascades. Depending on their design and mechanism, IL-6Rα inhibitors can bind directly to the receptor, blocking the interaction site for IL-6, or they might interfere with the conformational changes required for effective signaling. Others might inhibit the downstream signaling pathways activated upon IL-6/IL-6Rα/gp130 complex formation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib inhibits JAK1/JAK2 kinases, downstream of IL-6Rα, thereby suppressing signaling through the receptor. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
IKK-2 Inhibitor IV inhibits IKK-2 which is involved in the downstream signaling of IL-6Rα. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
Stattic selectively inhibits the activation of STAT3, a downstream molecule in the IL-6Rα pathway. | ||||||
Stat3 Inhibitor III, WP1066 | 857064-38-1 | sc-203282 | 10 mg | $132.00 | 72 | |
WP1066 is an inhibitor of STAT3, blocking its phosphorylation and nuclear translocation in the IL-6Rα signaling cascade. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is a JAK2 inhibitor, targeting the downstream signaling pathway of IL-6Rα. | ||||||
WHI-P 154 | 211555-04-3 | sc-204395 sc-204395A | 10 mg 50 mg | $153.00 $643.00 | 3 | |
WHI-P154 is a JAK3 inhibitor that can indirectly modulate the IL-6Rα signaling pathway. | ||||||
Nifuroxazide | 965-52-6 | sc-204128 sc-204128A | 500 mg 5 g | $203.00 $520.00 | 5 | |
Nifuroxazide is an inhibitor of STAT3, impacting the downstream signaling events of IL-6Rα. | ||||||
Cryptotanshinone | 35825-57-1 | sc-280649 | 10 mg | $119.00 | 1 | |
Cryptotanshinone inhibits STAT3 activation, thereby down-regulating signaling through IL-6Rα. | ||||||