Molecular structure of Cryptotanshinone, CAS Number: 35825-57-1
Cryptotanshinone (CAS 35825-57-1)
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Alternate Names:
Tanshinone c; 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione
Application:
Cryptotanshinone is inhibitor of STAT3 and AChE
CAS Number:
35825-57-1
Purity:
≥98%
Molecular Weight:
296.36
Molecular Formula:
C19H20O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cryptotanshinone is a potent inhibitor of certain cellular processes. It exerts its mechanism of action by targeting specific signaling pathways within cells, ultimately leading to the inhibition of cell proliferation and induction of apoptosis. Cryptotanshinone may modulate the activity of various proteins involved in cell cycle regulation and apoptosis, thereby disrupting the normal cellular processes. Cryptotanshinone interferes with the expression of certain genes involved in cancer progression, further contributing to its inhibitory effects on cell growth and survival.
Cryptotanshinone (CAS 35825-57-1) References
- In Silico Modeling of the Induction of Apoptosis by Cryptotanshinone in Osteosarcoma Cell Lines. | Saraf, R., et al. 2022. IEEE/ACM Trans Comput Biol Bioinform. 19: 1683-1693. PMID: 33180729
- Anti-tumor effects of cryptotanshinone (C19H20O3) in human osteosarcoma cell lines. | Vundavilli, H., et al. 2022. Biomed Pharmacother. 150: 112993. PMID: 35462337
- CTBP1‑AS upregulation is associated with polycystic ovary syndrome and can be effectively downregulated by cryptotanshinone. | Wen, M., et al. 2022. Mol Med Rep. 26: PMID: 35656892
- Cryptotanshinone ameliorates dextran sulfate sodium-induced murine acute and chronic ulcerative colitis via suppressing STAT3 activation and Th17 cell differentiation. | Fan, LM., et al. 2022. Int Immunopharmacol. 108: 108894. PMID: 35729830
- Cryptotanshinone Alleviates Oxidative Stress and Reduces the Level of Abnormally Aggregated Protein in Caenorhabditis elegans AD Models. | Cui, WB., et al. 2022. Int J Mol Sci. 23: PMID: 36077432
- Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model. | Sun, JM., et al. 2023. Environ Toxicol. 38: 39-48. PMID: 36124540
- Anticancer potential of cryptotanshinone on breast cancer treatment; A narrative review. | Dalil, D., et al. 2022. Front Pharmacol. 13: 979634. PMID: 36188552
- Cryptotanshinone modulates proliferation, apoptosis, and fibrosis through inhibiting AR and EGFR/STAT3 axis to ameliorate benign prostatic hyperplasia progression. | Wei, P., et al. 2023. Eur J Pharmacol. 938: 175434. PMID: 36462735
- Chemical Stability and Bioactivity of tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone in in vitro test systems. | Roth, A., et al. 2023. Toxicol Lett. 375: 21-28. PMID: 36563867
- Cryptotanshinone inhibits oral squamous cell carcinoma through the autophagic pathway. | Jiang, XT., et al. 2023. Neoplasma. 70: 114-122. PMID: 36704921
- [Effect of Rhizophagus intraradices on growth of Salvia miltiorrhiza]. | Zheng, LL., et al. 2023. Zhongguo Zhong Yao Za Zhi. 48: 349-355. PMID: 36725224
- Cryptotanshinone Attenuated Pathological Cardiac Remodeling In Vivo and In Vitro Experiments. | Li, WJ., et al. 2023. Oxid Med Cell Longev. 2023: 4015199. PMID: 36743695
- Preparation and optimization of surface stabilized cryptotanshinone nanocrystals with enhanced bioavailability. | Zhao, W., et al. 2023. Front Pharmacol. 14: 1122071. PMID: 36817118
Inhibitor of:
AChE, BC052484, C-MIP, G1P3, gp130, HES1, hnRNP A1, IFN-δ, IFN-γRα, IL-6Rα, KIAA1958, LIF, LIFR, MAZ, Paired Box (PAX), Pax-6, PAX9, Rev-erbα, SOCS-1, SOCS-6, Sox-21, Stat, Stat1, Stat3, TFIIH p44, V1RC25, V1RC32, V1rc5, and YY2.Activator of:
AMPK, SOCS-3, Stat3, and TRAF4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cryptotanshinone, 10 mg | sc-280649 | 10 mg | $117.00 |