Cryptotanshinone is a major tanshinone that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50 = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMPK (AMP-activated protein kinase). Also inhibits AChE (acetylcholinesterase) (IC50 = 4.09 μM) and reduction in Aβ peptide generation.
Soluble in DMSO (12 mg/ml at 25 °C), water (1 mg/ml at 25 °C), and ethanol (10 mg/ml at 25 °C).
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Xia et alXia et al. (PubMed ID 26356271) showed that Cryptotanshinone combined with cisplatin induced apoptosis by sensitizing A549/DDP cells and inhibiting the Nrf2 pathway in chemoresistant carcinoma cells. -SCBT Publication Review
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