Molecular structure of Stat3 Inhibitor III, WP1066, CAS Number: 857064-38-1
Stat3 Inhibitor III, WP1066 (CAS 857064-38-1)
See product citations (72)
Alternate Names:
(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
Application:
Stat3 Inhibitor III, WP1066 is a cell permeable inhibitor of Stat3 and JAK2 protein tyrosine kinase
CAS Number:
857064-38-1
Purity:
≥97%
Molecular Weight:
356.2
Molecular Formula:
C17H14BrN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Stat3 inhibitor III, WP1066 (WP10666) is a cell permeable AG 490 tyrphostin analog that effectively inhibits the STAT3 pathway. The inhibitor is a potent antitumor agent as displayed in the growth inhibition of malignant glioma cell and acute myelogenous leukemia cells. Stat3 Inhibitor III, WP1066 has shown more potency as an antitumor agent than AG 490 (sc-202046) when inhibiting malignant glioma growth in vitro. Stat3 inhibitor III, WP1066 also acts as an immune adjuvant by inducing proliferation of effector T cells and upregulating CD86 and CD80. In addition Stat3 inhibitor III, WP1066 has displayed inhibition of JAK2 protein tyrosine kinase as well as suggested activation of Bax.
Stat3 Inhibitor III, WP1066 (CAS 857064-38-1) References
- A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. | Iwamaru, A., et al. 2007. Oncogene. 26: 2435-44. PMID: 17043651
- A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. | Hussain, SF., et al. 2007. Cancer Res. 67: 9630-6. PMID: 17942891
- WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. | Ferrajoli, A., et al. 2007. Cancer Res. 67: 11291-9. PMID: 18056455
- WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. | Verstovsek, S., et al. 2008. Clin Cancer Res. 14: 788-96. PMID: 18245540
- Leptin attenuates cardiac apoptosis after chronic ischaemic injury. | McGaffin, KR., et al. 2009. Cardiovasc Res. 83: 313-24. PMID: 19233863
- STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma. | Horiguchi, A., et al. 2010. Br J Cancer. 102: 1592-9. PMID: 20461084
- The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models. | Hatiboglu, MA., et al. 2012. Int J Cancer. 131: 8-17. PMID: 21792892
- STAT3 inhibitor WP1066 as a novel therapeutic agent for bCCI neuropathic pain rats. | Xue, ZJ., et al. 2014. Brain Res. 1583: 79-88. PMID: 25084036
- WP1066 sensitizes oral squamous cell carcinoma cells to cisplatin by targeting STAT3/miR-21 axis. | Zhou, X., et al. 2014. Sci Rep. 4: 7461. PMID: 25514838
- The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. | Lu, K., et al. 2015. Cancer Lett. 359: 250-8. PMID: 25636517
- The STAT3 inhibitor WP1066 synergizes with vorinostat to induce apoptosis of mantle cell lymphoma cells. | Lu, K., et al. 2015. Biochem Biophys Res Commun. 464: 292-8. PMID: 26116769
- WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3. | Honda, S., et al. 2017. Cancer Sci. 108: 520-527. PMID: 28035720
- STAT3 inhibition by WP1066 suppresses the growth and invasiveness of bladder cancer cells. | Tsujita, Y., et al. 2017. Oncol Rep. 38: 2197-2204. PMID: 28849140
- Stat3/Oct-4/c-Myc signal circuit for regulating stemness-mediated doxorubicin resistance of triple-negative breast cancer cells and inhibitory effects of WP1066. | Cheng, CC., et al. 2018. Int J Oncol. 53: 339-348. PMID: 29750424
Inhibitor of:
BC052484, C-MIP, Cbl-b, CNTF, CRLF1, gp130, HSP 27, IFN-α7, IFN-δ, IFN-γRβ, IL-11, IL-27Rα, IL-29, IL-3R, IL-6Rα, ISG43, JAK, JAK2, KIAA1958, LEPROT, LIF, LIFR, p20-ARC, SOCS-1, SOCS-2, SOCS-4, SOCS-6, SPEER-3, Stat, Stat3, TNF receptor superfamily (TNFRSF), Transcription Factor, TSLPR, UBTD1, USP40, and USP52.Activator of:
Bax, CIS, GPATCH3, IL-10Rβ, Lnk, OTTMUSG00000016644, PLP-L, RBM10, and USP38.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat3 Inhibitor III, WP1066, 10 mg | sc-203282 | 10 mg | $132.00 |