IL-6Rα Activators
IL-6Rα activators form a heterogeneous group of chemicals that primarily function by influencing upstream or associated pathways that ultimately have an impact on IL-6Rα. Agents like Sodium Salicylate and Dexamethasone modulate transcription factors such as NF-κB or glucocorticoid receptor, which are known to influence the expression levels of IL-6Rα. Similarly, agents like Staurosporine and Phorbol 12-myristate 13-acetate (PMA) operate through protein kinase C, affecting the JAK/STAT pathway that is integral for IL-6Rα signaling. These chemicals do not directly interact with IL-6Rα but modulate pathways that lead to its activation or increased expression.
Another set of chemicals like Epidermal Growth Factor (EGF), Forskolin, and LPS function by manipulating the availability of IL-6 or affecting secondary messengers that engage in IL-6Rα signaling. For example, Forskolin increases cAMP levels, which further activates STAT3, a signaling molecule activated upon IL-6Rα engagement. EGF can elevate IL-6 levels, thereby providing more ligand to bind IL-6Rα.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Activates NF-κB, which can upregulate IL-6Rα expression. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
PKC activator that influences the JAK/STAT pathway, affecting IL-6Rα signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C, indirectly affecting IL-6Rα. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Increases cAMP levels, influencing IL-6Rα through STAT3 activation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Glucocorticoid receptor agonist; can increase IL-6Rα expression. | ||||||
Carnosol | 5957-80-2 | sc-204672 sc-204672A sc-204672B sc-204672C | 1 mg 5 mg 10 mg 50 mg | $85.00 $340.00 $590.00 $2595.00 | ||
Induces TLR4 signaling, which can elevate IL-6 levels and thereby affect IL-6Rα. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Calcium ionophore, affects IL-6 and thereby IL-6Rα signaling. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Beta-adrenergic agonist; activates cAMP pathway, which can influence IL-6Rα. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
PPARγ agonist; can increase IL-6 expression and influence IL-6Rα. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Sirtuin activator; can modulate IL-6 and thereby influence IL-6Rα. | ||||||