IL-5Rα Activators
The class of chemicals referred to as IL-5Rα activators includes a diverse range of compounds that can indirectly enhance the functional activity of IL-5Rα by influencing various cellular signaling pathways. Phorbol 12-myristate 13-acetate (PMA), for example, activates Protein Kinase C (PKC), which can increase phosphorylation in the pathway incorporating IL-5Rα. Similarly, Ionomycin, a calcium ionophore, prompts a rise in intracellular calcium concentration, which can stimulate the Calmodulin-dependent protein kinases (CaMKs) pathway linked to IL-5Rα. This, in turn, augments the functional activity of IL-5Rα. Forskolin, another IL-5Rα activator, enhances adenylyl cyclase activity, raising cyclic AMP (cAMP) levels in cells. This elevation of cAMP activates Protein Kinase A (PKA), which is connected to the IL-5Rα signaling pathway, thereby enhancing the functional activity of IL-5Rα.
IL-5Rα activators also include potent inhibitors of various kinases and enzymes, which indirectly stimulate IL-5Rα function by activating other signaling pathways. LY294002 and Wortmannin inhibit phosphoinositide 3-kinases (PI3Ks), leading to increased activity of the Jak/STAT pathway, directly linked to IL-5Rα. Similarly, PD98059, an inhibitor of MEK1, prompts a surge in Jak/STAT pathway activity. Genistein and PP2, inhibitors of protein tyrosine kinases and Src family tyrosine kinases respectively, also activate the Jak/STAT pathway. U73122, a phospholipase C (PLC) inhibitor, H89, a Protein Kinase A (PKA) inhibitor, SB203580, a p38 MAPK inhibitor, and SP600125, a Jun N-terminal Kinase (JNK) inhibitor, all enhance the Jak/STAT pathway activity linked to IL-5Rα, thereby indirectly boosting the functional activity of IL-5Rα.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), a family of serine- and threonine-specific protein kinases. PKC activation can lead to phosphorylation of downstream proteins in the signaling pathway that includes IL-5Rα. Enhanced phosphorylation in this pathway can increase the functional activity of IL-5Rα. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a well-known calcium ionophore that increases the intracellular calcium concentration ([Ca2+]i). The rise in [Ca2+]i can activate the Calmodulin-dependent protein kinases (CaMKs) pathway, which is connected with the IL-5Rα signaling pathway. The activation of CaMKs can enhance the functional activity of IL-5Rα. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which increases the levels of cyclic AMP (cAMP) in cells. Elevated cAMP levels can activate Protein Kinase A (PKA), which is connected to the IL-5Rα signaling pathway. Activation of PKA can enhance the functional activity of IL-5Rα. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Inhibition of PI3Ks can increase the activity of other pathways, such as the Jak/STAT pathway, which is directly linked to IL-5Rα. Thus, LY294002 can indirectly enhance the functional activity of IL-5Rα. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a non-ATP competitive inhibitor of MEK1. MEK1 inhibition can lead to an increase in the activity of other pathways, such as the Jak/STAT pathway, which is directly connected with IL-5Rα. This can indirectly enhance the functional activity of IL-5Rα. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of PI3Ks. Inhibition of PI3Ks can lead to the activation of other signaling pathways, such as the Jak/STAT pathway, which is directly connected with IL-5Rα. Thus, Wortmannin can indirectly enhance the functional activity of IL-5Rα. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a potent inhibitor of protein tyrosine kinases. Inhibition of these kinases can lead to the activation of other signaling pathways, such as the Jak/STAT pathway, which is directly connected with IL-5Rα. Thus, Genistein can indirectly enhance the functional activity of IL-5Rα. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a potent inhibitor of Src family tyrosine kinases. Inhibition of these kinases can lead to the activation of other signaling pathways, such as the Jak/STAT pathway, which is directly connected with IL-5Rα. Thus, PP2 can indirectly enhance the functional activity of IL-5Rα. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H89 is a potent inhibitor of Protein Kinase A (PKA). Inhibition of PKA can lead to the activation of other pathways, such as the Jak/STAT pathway, which is directly connected with IL-5Rα. Thus, H89 can indirectly enhance the functional activity of IL-5Rα. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a potent inhibitor of p38 MAPK. Inhibition of p38 MAPK can lead to the activation of other signaling pathways, such as the Jak/STAT pathway, which is directly connected with IL-5Rα. Thus, SB203580 can indirectly enhance the functional activity of IL-5Rα. | ||||||