IL-18 Activators
The chemical class known as IL-18 activators comprises a diverse array of compounds that modulate IL-18 expression by targeting the NF-κB signaling pathway. These chemicals, including resveratrol, curcumin, dexamethasone, thymoquinone, 3,3'-diindolylmethane (DIM), quercetin, sulforaphane, luteolin, sodium salicylate, epigallocatechin gallate (EGCG), alpha-lipoic acid, and celastrol, play crucial roles in relieving IL-18 from transcriptional suppression, thereby promoting its active participation in pro-inflammatory processes.
NF-κB serves as a central orchestrator in regulating IL-18 expression. These activators, through their distinct mechanisms, predominantly inhibit NF-κB, releasing IL-18 from its suppressive influence. For instance, resveratrol and curcumin act as potent inhibitors of NF-κB, facilitating increased IL-18 transcription. Dexamethasone, a glucocorticoid, further contributes to IL-18 activation by inhibiting both NF-κB and AP-1. Thymoquinone, DIM, quercetin, sulforaphane, luteolin, sodium salicylate, EGCG, alpha-lipoic acid, and celastrol exhibit similar NF-κB inhibitory effects, collectively supporting the activation of IL-18.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates IL-18 by inhibiting NF-κB, a key regulator of pro-inflammatory responses. This inhibition results in reduced IL-18 suppression, promoting its expression and contributing to enhanced inflammatory responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates IL-18 by suppressing the NF-κB pathway. Its inhibitory action on NF-κB signaling relieves IL-18 from suppression, allowing for increased expression and participation in inflammatory processes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone activates IL-18 by inhibiting NF-κB and AP-1, key transcription factors involved in its suppression. This inhibition relieves IL-18 from transcriptional restraint, promoting its expression and augmenting pro-inflammatory responses. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $46.00 $130.00 | 21 | |
Thymoquinone activates IL-18 by modulating the NF-κB pathway. Its influence on NF-κB signaling relieves IL-18 from inhibition, facilitating increased expression and participation in inflammatory reactions. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $36.00 $64.00 $87.00 $413.00 $668.00 $65.00 | 8 | |
DIM activates IL-18 by inhibiting NF-κB, a central regulator of its expression. This inhibition releases IL-18 from suppression, allowing for increased transcription and contribution to pro-inflammatory processes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates IL-18 by inhibiting the NF-κB pathway. Its action on NF-κB signaling alleviates IL-18 from inhibition, promoting its expression and involvement in inflammatory responses. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates IL-18 by inhibiting NF-κB, a key suppressor of its expression. This inhibition releases IL-18 from restraint, leading to increased expression and participation in pro-inflammatory cascades. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin activates IL-18 by suppressing NF-κB, a major inhibitor of its expression. This inhibition relieves IL-18 from suppression, fostering increased transcription and involvement in pro-inflammatory pathways. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium salicylate activates IL-18 by inhibiting NF-κB, a critical regulator of its expression. This inhibition releases IL-18 from suppression, promoting increased transcription and participation in pro-inflammatory responses. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG activates IL-18 by inhibiting the NF-κB pathway. Its action on NF-κB signaling alleviates IL-18 from inhibition, facilitating increased expression and involvement in inflammatory processes. | ||||||