IL-18 Inhibitors
Interleukin-18 (IL-18) is a pro-inflammatory cytokine that plays a significant role in modulating immune responses. Produced as an inactive precursor primarily by macrophages and other immune cells, IL-18 is cleaved by caspase-1 into its active form, which then exerts its biological effects by binding to the IL-18 receptor. This receptor is expressed on various cell types, including T cells, natural killer cells, and macrophages. Upon binding to its receptor, IL-18 acts synergistically with other cytokines, notably IL-12, to stimulate the production of interferon-gamma (IFN-γ), thereby promoting the Th1 immune response. Additionally, IL-18 can influence the secretion of other cytokines and chemokines, contributing to the orchestration of inflammatory responses. Given its pivotal role in mediating inflammation and immune reactions, the tight regulation of IL-18 activity is crucial for maintaining immune homeostasis and preventing excessive or chronic inflammation.
IL-18 inhibitors encompass a class of chemical compounds specifically designed to target and modulate the activity or release of IL-18. These inhibitors can operate through various mechanisms. Some might bind directly to IL-18, preventing its interaction with its receptor and thereby neutralizing its pro-inflammatory effects. Others might target the maturation process of IL-18, inhibiting the enzymes responsible for converting the inactive precursor into its active form. Additionally, some inhibitors could interfere with the signaling pathways activated by IL-18, dampening the downstream effects induced by this cytokine.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7085 | 196309-76-9 | sc-202490 sc-202490A | 10 mg 50 mg | $122.00 $516.00 | 55 | |
Bay 11-7085 inhibits NF-κB activation, which can be induced by IL-18. This compound may reduce IL-18-mediated cellular responses. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide also inhibits NF-κB activation. By targeting this pathway, it may reduce the effects of IL-18-mediated activation. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $66.00 $89.00 | 13 | |
SC-514 inhibits IKKβ, involved in the NF-κB pathway, which can be activated by IL-18, potentially reducing IL-18 effects. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a JNK inhibitor. The JNK pathway can be activated by IL-18, so inhibiting it might reduce IL-18 signaling effects. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
PDTC is an NF-κB inhibitor. By inhibiting this pathway, it may downregulate some effects of IL-18. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $103.00 $210.00 $6132.00 | 2 | |
Emodin has anti-inflammatory effects and might modulate IL-18's actions. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin has been shown to have anti-inflammatory effects, which could modulate IL-18's actions. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin, like other flavonoids, might have anti-inflammatory effects and could modulate the actions of IL-18. | ||||||