Molecular structure of 3,3′-Diindolylmethane, CAS Number: 1968-05-4
3,3′-Diindolylmethane (CAS 1968-05-4)
See product citations (8)
Alternate Names:
DIM; Plant Indole; 3,3′-Methylenediindole
Application:
3,3′-Diindolylmethane is an antineoplastic agent that activates Chk 2 and cytochrome p450
CAS Number:
1968-05-4
Purity:
≥98%
Molecular Weight:
246.31
Molecular Formula:
C17H14N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3,3′-Diindolylmethane is an anticancer and antineoplastic agent. 3,3′-Diindolylmethane induces apoptosis in human cancer cells. 3,3′-Diindolylmethane is also an activator of CYP (cytochrome P450) and Chk2 (checkpoint kinase 2) as well as a partial agonist of aryl hydrocarbon receptor (Ah Receptor). The compound is a dimer of indole-3-carbinol (sc-202662).
3,3′-Diindolylmethane (CAS 1968-05-4) References
- Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. | Nachshon-Kedmi, M., et al. 2003. Food Chem Toxicol. 41: 745-52. PMID: 12738179
- 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. | Chang, X., et al. 2005. Carcinogenesis. 26: 771-8. PMID: 15661811
- Oligomerization of indole-3-carbinol in aqueous acid. | Grose, KR. and Bjeldanes, LF. 1992. Chem Res Toxicol. 5: 188-93. PMID: 1643248
- Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. | Rahman, KW., et al. 2006. Cancer Res. 66: 4952-60. PMID: 16651453
- 3,3'-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages. | Cho, HJ., et al. 2008. J Nutr. 138: 17-23. PMID: 18156398
- 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. | Kim, YH., et al. 2009. Inflamm Bowel Dis. 15: 1164-73. PMID: 19334074
- Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. | Li, Y., et al. 2010. Cancer Res. 70: 646-54. PMID: 20068155
- Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic. | Banerjee, S., et al. 2011. Mutat Res. 728: 47-66. PMID: 21703360
- 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. | Beaver, LM., et al. 2012. Toxicol Appl Pharmacol. 263: 345-51. PMID: 22800507
- Encapsulation of indole-3-carbinol and 3,3'-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability. | Luo, Y., et al. 2013. Food Chem. 139: 224-30. PMID: 23561099
- DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. | Fan, S., et al. 2013. Proc Natl Acad Sci U S A. 110: 18650-5. PMID: 24127581
- Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies. | Thomson, CA., et al. 2016. Nutr Rev. 74: 432-43. PMID: 27261275
- Cellular and Molecular Mechanisms of 3,3'-Diindolylmethane in Gastrointestinal Cancer. | Kim, SM. 2016. Int J Mol Sci. 17: PMID: 27447608
- The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450. | Stresser, DM., et al. 1995. J Biochem Toxicol. 10: 191-201. PMID: 8568833
Inhibitor of:
1110001A16Rik, 1110017F19Rik, 1190007F08Rik, 1600014C23Rik, 1700008P20Rik, 1700017D01Rik, 1700023F06Rik, 1700026J04Rik, 1700129C05Rik, 1810024B03Rik, 2010315B03Rik, 2210010C04Rik, 2210020M01Rik, 2300003K06Rik, 2410017P09Rik, 4930415L06Rik, 4930428E23Rik, 4930467E23Rik, 4930523C07Rik, 4930579G24Rik, AFP Receptor, apoL7b, BRWD1, C4orf47, CD66CE, Collagen Type IV-α2, CXorf30, CXorf51, Cytokeratin 13, Dcun1D2, DDX60L, E2F-2, Etohi1, FOXE1, GalNAc-T8, Gm10471, Gm14195, HAX-1, HPV 18-E7, IMPA1, IMPA2, KLK11, MGST3, neuroligin 1, OR10Q1, PAC-1, PC-1, PCDHGB6, PEA3, PRC1, PROX1, PUMA, Reg Iα, Reg Iβ, Rhox3g, SULT1A2, SULT1C1, SULT2A5, TNF Superfamily (TNFSF), TRAIL, U2AF26, UGT2B10, UGT2B28, and VEGI.Activator of:
AEBP2, Ah Receptor, ALDH1A1, ARID1A, Arnt 1, Aryl Hydrocarbon Receptor, AZ3, BEND5, BET3, C1orf110, C1orf131, C1orf192, C1orf50_AU022252, C1orf53, C1orf54, C1orf89, casein kinase Iδ, Chk2, CHST12, CMBL, Complexin-1, CYP, Cyp4f16, DEHAL1, Dynactin 6, EHD1, Elastase-3B, Filensin, FMO9, FOXA3, FOXO1, FOXO3, FSH, Gβ 4, GPR156, GPR172A, GSDMC4, H2-M10.6, HEL308, HRP-3, HYAL6, IL-18, INSM1, Intectin, IQCF1, KAO, KLF17, LCRISP2, Lipocalin-5, LOC100039452, LOC100039560, LOC100039799, LOC100039934, LOC100040657, LOC100040923, LOC100041004, LOC100041054, LOC100041179, LOC100041250, LOC100041253, LRRC3, LSAMP, MAB21L3, MCTS1, NCoA-3, NELF-A, nephrocystin-5, Neurofascin, NOD2, OR2A1, OTTMUSG00000010546, OVCA2, PACT, PADI6, Pdcd-4, PRAMEF1, PRDM3, PTPN13LY, Ptpn23, RASSF1B, RASSF1E, RASSF1G, RTP3, SC35, SEC22A, SEP15, SULT4A1, TCF19, TERT, TPRG1, Txl-2, UGT1A7, UGT2B35, UGT3A1, WDR38, XAP2, ZCWPW2, ZFP64, ZNF136, and ZNF581.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,3′-Diindolylmethane, 100 mg | sc-204624 | 100 mg | $36.00 | |||
3,3′-Diindolylmethane, 500 mg | sc-204624A | 500 mg | $64.00 | |||
3,3′-Diindolylmethane, 1 g | sc-204624E | 1 g | $65.00 | |||
3,3′-Diindolylmethane, 5 g | sc-204624B | 5 g | $87.00 | |||
3,3′-Diindolylmethane, 10 g | sc-204624C | 10 g | $413.00 | |||
3,3′-Diindolylmethane, 50 g | sc-204624D | 50 g | $668.00 |