IL-17RE Activators
Interleukin-17 receptor E (IL-17RE) is an integral component of the IL-17 receptor family, holding significance in the orchestration of immune responses. The family of chemicals known as IL-17RE Activators comprises various compounds that can indirectly influence the function and signaling of IL-17RE. These compounds typically target distinct cellular pathways closely associated with IL-17RE activity, thus serving as indirect modulators of its functionality.
Among the notable compounds, Phorbol 12-myristate 13-acetate (PMA) stands out as a potent activator of protein kinase C (PKC), which is intricately linked to IL-17 signaling pathways. U0126, a selective inhibitor for MEK1 and MEK2, along with SB203580, a p38 MAPK inhibitor, can modify the signaling cascades emanating from IL-17RE. The phosphoinositide 3-kinases (PI3K) inhibitors, Ly294002 and Wortmannin, affect the Akt pathway, thereby influencing IL-17 responses. Furthermore, SP600125, a JNK inhibitor, and BAY 11-7082, which impedes NF-κB activation, directly influence downstream pathways of IL-17 signaling. Cyclosporin A can exert an effect on IL-17 producing cells, thereby indirectly influencing IL-17RE, while Ionomycin, as a calcium ionophore, plays a role in elevating intracellular calcium levels and modulating numerous signaling pathways. Lastly, IKK Inhibitor VII and Anisomycin act on the IKK and JNK pathways respectively, both of which are implicated in IL-17 mediated signaling.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diester of phorbol that acts as a protein kinase C (PKC) activator, which can be involved in IL-17 signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor. p38 MAPK can be activated downstream of IL-17 signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that can influence Akt and other pathways linked to IL-17 responses. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor. The JNK pathway can be activated downstream of IL-17 signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibitor of NF-κB activation. NF-κB plays a crucial role in IL-17 mediated inflammatory responses. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Immunosuppressive agent that can affect IL-17 producing cells, potentially influencing IL-17RE indirectly. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore, which can raise intracellular calcium levels, influencing various signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor, affecting Akt and pathways potentially associated with IL-17 responses. | ||||||
[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone | 873225-46-8 | sc-503387 | 10 mg | $430.00 | ||
A specific inhibitor of IKK that can impede NF-κB activation, related to IL-17 signaling. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
A JNK activator which can influence IL-17-mediated responses indirectly through JNK signaling. | ||||||