IGSF3 Inhibitors
IGSF3 inhibitors are a class of compounds that specifically target and interfere with the function of the immunoglobulin superfamily member 3 (IGSF3), a cell surface glycoprotein that plays a critical role in cell adhesion and signaling. IGSF3, like other members of the immunoglobulin superfamily, is characterized by the presence of multiple immunoglobulin-like domains that facilitate interactions between cells and the extracellular environment. These interactions are vital for maintaining proper cellular communication, structural integrity, and coordination during various biological processes. The inhibition of IGSF3 can potentially disrupt these cellular interactions, which may lead to changes in cell behavior, such as alterations in migration, differentiation, or cell-cell communication.
Structurally, IGSF3 inhibitors are designed to bind selectively to functional regions of the IGSF3 protein, particularly its extracellular domains responsible for mediating adhesion and signaling events. This selective binding may involve various chemical interactions, such as hydrogen bonding, van der Waals forces, or hydrophobic interactions, that stabilize the inhibitor in place and effectively block the protein's natural activity. The development of IGSF3 inhibitors often requires a deep understanding of the protein's three-dimensional structure to ensure precise targeting and effective modulation. These inhibitors are valuable tools in biochemical research, as they allow for the detailed study of IGSF3's role in cellular pathways and processes, providing insights into how this protein influences cell dynamics and function within complex biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that blocks phosphatidylinositol 3-kinase activity. Since PI3K signaling is involved in various cellular processes, affecting this pathway can potentially modulate proteins like IGSF3, which may interact with downstream components of the pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent, irreversible PI3K inhibitor. By inhibiting the PI3K pathway, it can have an impact on associated proteins, potentially including IGSF3. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
ERK pathway inhibitor that blocks MEK1 activation. Given that many proteins, potentially including IGSF3, may be indirectly regulated by ERK signaling, modulating this pathway can influence IGSF3 functionality. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor. The JNK pathway is integral for various cellular functions. Inhibition of this pathway can affect multiple proteins and may influence IGSF3, depending on its integration into the pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor. By modulating the p38 MAPK signaling, it can have indirect effects on proteins associated or regulated by this pathway, possibly including IGSF3. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor. mTOR signaling is crucial for cell growth and proliferation. Inhibiting this pathway can influence a host of proteins, potentially including IGSF3, depending on its involvement. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $204.00 $265.00 | 29 | |
Specific inhibitor of Akt1 and Akt2 isoforms. Since Akt is a downstream effector of PI3K, influencing its activity can have ripple effects on proteins potentially associated with the PI3K-Akt pathway, including IGSF3. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
NF-κB pathway inhibitor. The NF-κB pathway is involved in inflammation and immune responses. Modulating this pathway can potentially impact proteins like IGSF3, if they are associated with or regulated by NF-κB signaling. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
IP3 receptor inhibitor. Given that the IP3 signaling is integral for various cellular functions, modulating this can have an impact on many proteins, potentially including IGSF3, depending on its role in the pathway. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor. The Rho-associated kinase (ROCK) pathway plays a role in various cellular processes. Inhibition can have a cascading effect on proteins associated with the pathway, potentially including IGSF3. | ||||||