IGFBP1 Inhibitors
IGFBP1 inhibitors are a class of chemical compounds that specifically target and modulate the activity of Insulin-like Growth Factor Binding Protein 1 (IGFBP1). IGFBP1 is a crucial component of the insulin-like growth factor (IGF) system, which plays a fundamental role in regulating cell growth, proliferation, and differentiation. This class of inhibitors is designed to interact with IGFBP1, thereby affecting its function within the IGF system. IGFBP1's primary function is to bind to IGFs, specifically IGF-1 and IGF-2, and modulate their bioavailability and activity by regulating their transport and release from binding proteins. By inhibiting IGFBP1, these compounds can potentially alter the balance of free IGFs in the body, ultimately influencing cell signaling pathways involved in growth and development.
IGFBP1 inhibitors may operate through various mechanisms, such as blocking the binding sites on IGFBP1 that interact with IGFs, preventing its release of IGFs, or interfering with its stability and expression. By doing so, these inhibitors can fine-tune the levels of free IGFs in the circulation and localized tissues, which can have a profound impact on cellular processes like cell proliferation, differentiation, and apoptosis. This class of compounds holds promise in advancing our understanding of the IGF system's intricate regulatory mechanisms and its role in various physiological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AG 1024 | 65678-07-1 | sc-205907 | 1 mg | $107.00 | 22 | |
AG1024 is a tyrosine kinase inhibitor that has been studied for its potential to inhibit the IGF-1 receptor and downstream signaling pathways, including IGFBP-1. | ||||||
NVP-AEW541 | 475489-16-8 | sc-507395 | 5 mg | $285.00 | ||
This small molecule inhibitor targets the IGF-1 receptor and has been explored for its effects on IGFBP-1 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor that can indirectly affect IGFBP-1 expression by modulating the PI3K/AKT pathway, which is involved in IGF-1 signaling. | ||||||
BMS-754807 | 1001350-96-4 | sc-507396 | 5 mg | $304.00 | ||
BMS-754807 is another IGF-1 receptor inhibitor that has been studied for its impact on IGFBP-1 and IGF-1 signaling. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Fisetin is a natural flavonoid found in various fruits and vegetables. It has been investigated for its ability to inhibit the IGF-1 receptor and subsequently reduce IGFBP-1 levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in red wine and certain plants. It has been examined for its potential to modulate IGF-1 signaling and IGFBP-1 expression. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin is a commonly used agent in research for type 2 diabetes. It may indirectly affect IGFBP-1 through its impact on insulin sensitivity and IGF-1 signaling. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is a natural compound found in various plants, including goldenseal and barberry. It has been investigated for its potential to influence IGF-1 signaling and IGFBP-1 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a bioactive compound found in turmeric. It has been studied for its anti-inflammatory and potential IGF-1 inhibitory effects, which could impact IGFBP-1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea. It has been explored for its potential to interfere with IGF-1 signaling pathways and potentially affect IGFBP-1 levels. | ||||||