NVP-AEW541 (CAS 475489-16-8)
Alternate Names:
AEW-541
CAS Number:
475489-16-8
Molecular Weight:
439.60
Molecular Formula:
C27H29N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SDS & Certificate of Analysis
NVP-AEW541 is a dual inhibitor of IGF-IR and InsR.
NVP-AEW541 (CAS 475489-16-8) References
- In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. | García-Echeverría, C., et al. 2004. Cancer Cell. 5: 231-9. PMID: 15050915
- Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors. | Scotlandi, K., et al. 2005. Cancer Res. 65: 3868-76. PMID: 15867386
- The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells. | Maiso, P., et al. 2008. Br J Haematol. 141: 470-82. PMID: 18341634
- Treatment of biliary tract cancer with NVP-AEW541: mechanisms of action and resistance. | Wolf, S., et al. 2010. World J Gastroenterol. 16: 156-66. PMID: 20066734
- Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. | Premkumar, DR., et al. 2010. Int J Oncol. 37: 633-43. PMID: 20664932
- Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines. | Attias-Geva, Z., et al. 2011. Gynecol Oncol. 121: 383-9. PMID: 21295335
- Esophageal cancer exhibits resistance to a novel IGF-1R inhibitor NVP-AEW541 with maintained RAS-MAPK activity. | Bao, XH., et al. 2012. Anticancer Res. 32: 2827-34. PMID: 22753744
- Two old drugs, NVP-AEW541 and GSK-J4, repurposed against the Toxoplasma gondii RH strain. | Liu, S., et al. 2020. Parasit Vectors. 13: 242. PMID: 32393321
- Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction. | Feng, L., et al. 2022. Am J Physiol Cell Physiol. 322: C164-C176. PMID: 34852207
- The IGF-1R Inhibitor NVP-AEW541 Causes Insulin-Independent and Reversible Cardiac Contractile Dysfunction. | Schenkl, C., et al. 2022. Biomedicines. 10: PMID: 36009569
Inhibitor of:
A2LD1, ACAT-2, BZW1, ErbB-3, IGF-I, IGF-IA, IGF-IB, IGF-II, IGF-IIR, IGF-IR, IGF-IRα, IGF-IRβ, IGFBP1, IGFBP3, IGFBP4, IGFBP6, IGFBPL1, IGFL2, INSL4, insulin R, IRS-1, and IRS-2.Activator of:
PAPP-A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NVP-AEW541, 5 mg | sc-507395 | 5 mg | $285.00 |