HoxD3 Inhibitors
HoxD3 inhibitors belong to a distinctive chemical class designed to modulate the activity of the HoxD3 gene. The HoxD3 gene is a member of the Hox family of transcription factors, which play crucial roles in embryonic development and cellular differentiation. Specifically, HoxD3 is involved in the regulation of gene expression patterns that dictate the development of various tissues and organs, contributing to the overall body plan. The inhibitors targeting HoxD3 aim to disrupt its normal function, thereby altering the downstream genetic cascades it governs.
HoxD3 inhibitors are typically small organic molecules that interact with the regulatory regions of the HoxD3 gene or its protein product. These inhibitors function by binding to specific sites on the HoxD3 transcription factor, hindering its ability to bind to DNA and initiate the transcription of target genes. This interference leads to a cascade effect, influencing the expression of downstream genes involved in cellular differentiation and development. Researchers are actively exploring the structural and mechanistic aspects of HoxD3 inhibitors to gain insights into their precise mode of action and optimize their potency and selectivity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Inhibits DNA methyltransferases, potentially reducing methylation and thus affecting HoxD3 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
HDAC inhibitor that can alter chromatin structure, potentially influencing HoxD3 activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A cytosine analog that inhibits DNA methyltransferases, may affect HoxD3 expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Aldehyde dehydrogenase inhibitor, indirectly might affect epigenetic regulation, thereby affecting HoxD3 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Isoflavone that may act as a tyrosine kinase inhibitor, indirectly influencing cellular pathways involving HoxD3. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of Vitamin A that regulates gene expression, including potentially that of HoxD3. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A diterpene triepoxide that can modulate transcription factors and gene expression, possibly affecting HoxD3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
A compound from turmeric that can modulate transcription factors and affect gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A stilbenoid that can influence various signaling pathways and gene expression patterns. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid that has been shown to affect signal transduction and gene expression. | ||||||