HoxB9 Activators
HoxB9 activators encompass various chemicals that, while not directly binding to or enhancing the function of HoxB9, can indirectly influence its activity by acting on the signaling pathways that HoxB9 is involved in. Insulin, an activator of the PI3K/Akt/mTOR pathway, Metformin and AICAR, both AMPK activators, along with the omega-3 fatty acids Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA), and the polyphenols Resveratrol, Curcumin, and Quercetin, can all stimulate the PI3K/Akt/mTOR pathway. This pathway is known to be utilized by HoxB9, so the activation of this pathway by these chemicals can indirectly lead to an increase in HoxB9 activity.
Additionally, Forskolin, which activates adenylate cyclase leading to increased cAMP levels, H-89, a PKA activator, and Phorbol 12-myristate 13-acetate (PMA), a potent activator of Protein Kinase C (PKC), can interact with the PI3K/Akt/mTOR pathway, hence leading to an indirect upregulationof HoxB9. Furthermore, BAPTA-AM, a calcium chelator, can indirectly influence HoxB9 activity through its action on the calcium-dependent CaMK pathway. When these chemicals interact with their respective targets, signals are transmitted through a series of molecular interactions, eventually influencing the PI3K/Akt/mTOR pathway and, in turn, modulating the activity of HoxB9. These chemicals can be seen as indirect HoxB9 activators due to their ability to regulate the signaling pathways that HoxB9 is part of, thereby influencing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt/mTOR pathway, which HoxB9 can utilize for its activity. Insulin's activation of this pathway can lead to an indirect upregulation of HoxB9. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, which can stimulate the PI3K/Akt/mTOR pathway. Since HoxB9 acts through this pathway, Metformin can indirectly lead to an increase in HoxB9 activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMPK activator. By activating AMPK, it can stimulate the PI3K/Akt/mTOR pathway, which HoxB9 uses, leading to an indirect increase in HoxB9 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. This can stimulate the PKA pathway, which can interact with the PI3K/Akt/mTOR pathway, leading to an indirect increase in HoxB9 activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a calcium chelator, and by increasing intracellular calcium levels, it can activate the CaMK pathway. The activation of this pathway can lead to an indirect increase in HoxB9 activity through crosstalk with the PI3K/Akt/mTOR pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC can interact with the PI3K/Akt/mTOR pathway, which HoxB9 uses, leading to an indirect increase in HoxB9 activity. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
EPA is an omega-3 fatty acid that can activate the PI3K/Akt/mTOR pathway. Since HoxB9 uses this pathway for its activity, EPA can indirectly increase HoxB9 activity. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA is another omega-3 fatty acid that can activate the PI3K/Akt/mTOR pathway. This can lead to an indirect increase in HoxB9 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate Sirtuin 1 (SIRT1), which can influence the PI3K/Akt/mTOR pathway. This can indirectly increase the activity of HoxB9. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate the PI3K/Akt/mTOR pathway, which HoxB9 utilizes for its activity. Thus, Curcumin can indirectly increase HoxB9 activity. | ||||||