hnRNP A2/B1 Activators
Common hnRNP A2/B1 Activators include, but are not limited to Sodium Butyrate CAS 156-54-7, Trichostatin A CAS 58880-19-6, Valproic Acid CAS 99-66-1, Resveratrol CAS 501-36-0 and Curcumin CAS 458-37-7.
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) is involved in various aspects of mRNA processing and transport. Dysregulation of hnRNP A2/B1 has been linked to various pathological conditions, including cancer and neurodegenerative disorders. hnRNP A2/B1 Activators belong to a chemical class that interacts with and influences the function of heterogeneous nuclear ribonucleoproteins A2 (hnRNP A2) and B1 (hnRNP B1). These proteins are part of the hnRNP family, which plays a crucial role in regulating pre-mRNA splicing, RNA processing, and gene expression. By modulating the activity of hnRNP A2/B1, these activators impact various cellular processes at the molecular level.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are essential components of the cell's machinery for processing RNA molecules. hnRNP A2/B1 Activators may influence the binding, localization, or post-translational modifications of hnRNP A2 and B1, which can, in turn, affect their roles in RNA metabolism. Understanding the effects of activators on these hnRNPs is critical for unraveling the intricate regulatory mechanisms governing gene expression and RNA processing within cells. Researchers are keen to explore the precise molecular interactions and cellular consequences of hnRNP A2/B1 activation, which may provide insights into fundamental biological processes and uncover new strategies for modulating gene expression and RNA processing in various contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate acts as a histone deacetylase (HDAC) inhibitor, leading to hnRNP A2/B1 upregulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs), resulting in hnRNP A2/B1 induction. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid functions as an HDAC inhibitor, promoting hnRNP A2/B1 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates AMP-activated protein kinase (AMPK), leading to hnRNP A2/B1 upregulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates multiple signaling pathways, including NF-κB, resulting in hnRNP A2/B1 induction. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can alter epigenetic regulation, potentially leading to hnRNP A2/B1 upregulation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist that can induce hnRNP A2/B1 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), leading to the upregulation of hnRNP A2/B1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG modulates multiple signaling pathways, including PI3K/Akt, leading to hnRNP A2/B1 induction. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that can induce hnRNP A2/B1 expression. | ||||||