Histone H2BM Activators
Histone deacetylase inhibitors like Trichostatin A, Sodium butyrate, and SAHA (Vorinostat) enhance histone acetylation levels, affecting Histone H2BM and its role in chromatin remodeling. Increased acetylation generally leads to a more open chromatin structure, facilitating gene transcription. In contrast, inhibitors of histone methyltransferases (like Methylstat and BIX-01294) and DNA methyltransferases (such as 5-Azacytidine and RG108) can alter the methylation landscape, indirectly impacting Histone H2BM and gene expression regulation.
Compounds like Curcumin, which influences multiple cellular pathways, and JQ1, targeting BET bromodomains, represent broader approaches to modulating chromatin dynamics and affecting Histone H2BM. Inhibitors of histone acetyltransferases, including Anacardic Acid, Disulfiram, and C646, also contribute to the regulation of histone acetylation, indirectly influencing the function and role of Histone H2BM in chromatin structure.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor, increases acetylation levels on histones, potentially influencing the structure and function of chromatin including Histone H2BM. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Another histone deacetylase inhibitor, promotes acetylation, potentially affecting Histone H2BM and chromatin accessibility. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase inhibitor, affects gene expression by altering histone acetylation, potentially impacting Histone H2BM. | ||||||
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
A histone methyltransferase inhibitor, could indirectly influence the methylation status of Histone H2BM. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Inhibits DNA methyltransferases, leading to changes in DNA methylation and potentially influencing histone modification patterns including H2BM. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
Another DNA methyltransferase inhibitor, alters DNA methylation, potentially impacting histone modification and H2BM activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural compound that can affect various signaling pathways and potentially influence histone modifications and H2BM activity. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Inhibits BET bromodomains, potentially influencing chromatin structure and indirectly affecting Histone H2BM. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Inhibits histone acetyltransferase, which could indirectly influence the acetylation status of Histone H2BM. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
A compound that inhibits acetyltransferases, potentially affecting histone acetylation and Histone H2BM function. | ||||||